Pyrathiazine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414767

CAS#: 84-08-2

Description: Pyrathiazine, a member of phenothiazines, is a histamine receptor antagonist used for the treatment of allergic diseases.

Chemical Structure

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Pyrathiazine
CAS# 84-08-2
Instruction

Theoretical Analysis

MedKoo Cat#: 414767
Name: Pyrathiazine
CAS#: 84-08-2
Chemical Formula: C18H20N2S
Exact Mass: 296.13
Molecular Weight: 296.430
Elemental Analysis: C, 72.93; H, 6.80; N, 9.45; S, 10.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Pyrathiazine; Parathiazinum; Parathiazine; Paratiazina

IUPAC/Chemical Name: Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-

InChi Key: KJKJUXGEMYCCJN-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H20N2S/c1-3-9-17-15(7-1)20(14-13-19-11-5-6-12-19)16-8-2-4-10-18(16)21-17/h1-4,7-10H,5-6,11-14H2

SMILES Code: C12=CC=CC=C1N(CCN3CCCC3)C4=C(C=CC=C4)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 296.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: PYRATHIAZINE hydrochloride. J Am Med Assoc. 1956 Aug 4;161(14):1384. PMID: 13331807.

2: Wrenn TR, Bitman J, Wood JR. Uterine deciduoma induction: comparison of direct mechanical trauma with systemic pyrathiazine. J Endocrinol. 1967 Mar;37(3):289-96. doi: 10.1677/joe.0.0370289. PMID: 4381300.

3: MARCUS GJ, KRAICER PF, SHELESNYAK MC. Studies on the mechanism of decidualization. II. Histamine-releasing action of pyrathiazine. J Reprod Fertil. 1963 Jun;5:409-15. doi: 10.1530/jrf.0.0050409. PMID: 13932916.

4: SHELESNYAK MC, KRAICER PF. Pyrathiazine is an antihistaminic capable of inducing uterine deciduomas by liberation of histamine within the body. C R Hebd Seances Acad Sci. 1959 Apr 6;248(14):2126-8. English, French. PMID: 13652441.

5: BARTLET AL. THE ACTION OF HISTAMINE ON THE ISOLATED HEART. Br J Pharmacol Chemother. 1963 Dec;21(3):450-61. doi: 10.1111/j.1476-5381.1963.tb02013.x. PMID: 14110745; PMCID: PMC1703891.

6: BROWN HW, CHAN KF, YOLKEN H. Efficacy of promethazine and pyrathiazine against enterobiasis. J Am Med Assoc. 1956 Nov 10;162(11):1049-51. doi: 10.1001/jama.1956.72970280001011. PMID: 13366707.

7: Castro-Vázquez A, Gómez E, De Carli DN, Rosner JM. Further evidence for histamine facilitating oestrogen action in the uterus. J Endocrinol. 1976 Jan;68(1):121-6. doi: 10.1677/joe.0.0680121. PMID: 3616.

8: Barkai U, Kidron T, Kraicer PF. Inhibition of decidual induction in rats by clomiphene and tamoxifen. Biol Reprod. 1992 Apr;46(4):733-9. doi: 10.1095/biolreprod46.4.733. PMID: 1576272.

9: Vladimirsky F, Chen L, Amsterdam A, Zor U, Lindner HR. Differentiation of decidual cells in cultures of rat endometrium. J Reprod Fertil. 1977 Jan;49(1):61-8. doi: 10.1530/jrf.0.0490061. PMID: 833790.

10: DELMAS-MARSALET P, FAURE J, ARNE L. Mécanisme d'action du diéthylamino- éthyl-N-dibenzo-parathiazine sur l'hypertonie extrapyramidale [Mechanism of action of diethylamino-ethyl-N-dibenzo-parathiazine on extrapyramidal hypertonia]. C R Seances Soc Biol Fil. 1950 Sep;144(17-18):1163-5. Undetermined Language. PMID: 14801876.