Palmatine iodide

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MedKoo CAT#: 414741

CAS#: 4880-79-9 (iodide)

Description: Palmatine iodide is a protoberberine alkaloid. Palmatine is major component of herbal preparations mainly used in traditional medicine Chinese, Korean and Indian. Palmatine can be found in various medicinal plants such as Coptis chinensis, Rhizoma coptidis, Corydalis yanhusuo, Radix tinosporae, among others. It exerts diverse pharmacological and biological properties. Palmatine has been proposed as a promising DNA phototherapy drug, notably due to its ability to produce in situ singlet oxygen only when interacting with DNA.

Chemical Structure

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Palmatine iodide
CAS# 4880-79-9 (iodide)
Instruction

Theoretical Analysis

MedKoo Cat#: 414741
Name: Palmatine iodide
CAS#: 4880-79-9 (iodide)
Chemical Formula: C21H23INO4+
Exact Mass: 0.00
Molecular Weight: 480.320
Elemental Analysis: C, 52.51; H, 4.83; I, 26.42; N, 2.92; O, 13.32

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 4880-79-9 (iodide); 3486-67-7 (free base); 10605-02-4 (Cl)  

Synonym: Palmatine iodide

IUPAC/Chemical Name: Dibenzo(a,g)quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy-, hydriodide

InChi Key: VUGARESHFWNHTD-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H22NO4.HI/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;

SMILES Code: COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(OC)C=C4CC3)C=C2C=C1.[H]I

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 480.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Long J, Song J, Zhong L, Liao Y, Liu L, Li X. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019 Jul;162:176-184. doi: 10.1016/j.biochi.2019.04.008. Epub 2019 Apr 30. PMID: 31051209.

2: Mai CT, Wu MM, Wang CL, Su ZR, Cheng YY, Zhang XJ. Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation. Mol Immunol. 2019 Jan;105:76-85. doi: 10.1016/j.molimm.2018.10.015. Epub 2018 Nov 27. PMID: 30496979.

3: Ekeuku SO, Pang KL, Chin KY. Palmatine as an Agent Against Metabolic Syndrome and Its Related Complications: A Review. Drug Des Devel Ther. 2020 Nov 17;14:4963-4974. doi: 10.2147/DDDT.S280520. PMID: 33235437; PMCID: PMC7680161.

4: Tarabasz D, Kukula-Koch W. Palmatine: A review of pharmacological properties and pharmacokinetics. Phytother Res. 2020 Jan;34(1):33-50. doi: 10.1002/ptr.6504. Epub 2019 Sep 8. PMID: 31496018.

5: Zhang XJ, Yuan ZW, Qu C, Yu XT, Huang T, Chen PV, Su ZR, Dou YX, Wu JZ, Zeng HF, Xie Y, Chen JN. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota. Pharmacol Res. 2018 Nov;137:34-46. doi: 10.1016/j.phrs.2018.09.010. Epub 2018 Sep 19. PMID: 30243842.

6: Liu L, He L, Yin C, Huang R, Shen W, Ge H, Sun M, Li S, Gao Y, Xiong W. Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia. Sci Rep. 2020 Mar 19;10(1):4998. doi: 10.1038/s41598-020-61969-1. PMID: 32193501; PMCID: PMC7081188.

7: Chaves SKM, Afzal MI, Islam MT, Hameed A, Da Mata AMOF, Da Silva Araújo L, Ali SW, Rolim HML, De Medeiros MDGF, Costa EV, Salehi B, Martins N, Arif AM, Imran M, Sharifi-Rad J, Melo-Cavalcante AAC, Feitosa CM. Palmatine antioxidant and anti-acetylcholinesterase activities: A pre-clinical assessment. Cell Mol Biol (Noisy-le-grand). 2020 Jun 25;66(4):54-59. PMID: 32583771.

8: Ma H, Zhang Y, Wang J, Guo W, Hu G, Xie S, Yang Z, Liu J, Fu S. Palmatine attenuates LPS-induced inflammatory response in mouse mammary epithelial cells through inhibiting ERK1/2, P38 and Akt/NF-кB signalling pathways. J Anim Physiol Anim Nutr (Berl). 2021 Jan;105(1):183-190. doi: 10.1111/jpn.13440. Epub 2020 Aug 31. PMID: 32865324.

9: Tian X, Zhang Y, Li H, Li Y, Wang N, Zhang W, Ma B. Palmatine ameliorates high fat diet induced impaired glucose tolerance. Biol Res. 2020 Sep 14;53(1):39. doi: 10.1186/s40659-020-00308-0. PMID: 32928312; PMCID: PMC7491132.

10: He L, Liu L, Guan S, Zheng X, Ge H, Yin C, Shen Y, Tan M, Wang C, Gao Y, Xiong W. Palmatine alleviates hyperalgesia by inhibiting the expression of calcitonin gene-related peptide in the trigeminal ganglion of rats with chronic constriction injury of the infraorbital nerve. Br J Oral Maxillofac Surg. 2020 May;58(4):443-450. doi: 10.1016/j.bjoms.2020.01.031. Epub 2020 Mar 2. PMID: 32139146.