Rupatadine Free Base | CAS# 158876-82-5 (free base) | antihistamine and platelet-activating factor antagonist

Rupatadine Free Base
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414735

CAS#: 158876-82-5 (free base)

Description: Rupatadine Free Base is a second generation antihistamine and platelet-activating factor antagonist used to treat allergies.

Chemical Structure

Rupatadine Free Base

CAS# 158876-82-5 (free base)

Instruction

Theoretical Analysis

MedKoo Cat#: 414735
Name: Rupatadine Free Base
CAS#: 158876-82-5 (free base)
Chemical Formula: C26H26ClN3
Exact Mass: 415.18
Molecular Weight: 415.970
Elemental Analysis: C, 75.08; H, 6.30; Cl, 8.52; N, 10.10

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 300	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 158876-82-5 (free base); 182349-12-8 (fumarate)

Synonym: Rupatadine Free Base; Pafinur; Rinialer; Alergoliber; Rupax

IUPAC/Chemical Name: 5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(1-((5-methyl-3-pyridinyl)methyl)-4-piperidinylidene)-

InChi Key: WUZYKBABMWJHDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H26ClN3/c1-18-13-19(16-28-15-18)17-30-11-8-20(9-12-30)25-24-7-6-23(27)14-22(24)5-4-21-3-2-10-29-26(21)25/h2-3,6-7,10,13-16H,4-5,8-9,11-12,17H2,1H3

SMILES Code: CC1=CN=CC(CN2CC/C(CC2)=C3C4=CC=C(Cl)C=C4CCC5=CC=CN=C5\3)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 415.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nettis E, Delle Donne P, Di Leo E, Calogiuri GF, Ferrannini A, Vacca A. Rupatadine for the treatment of urticaria. Expert Opin Pharmacother. 2013 Sep;14(13):1807-13. doi: 10.1517/14656566.2013.813481. Epub 2013 Jun 28. PMID: 23806068.

2: González-Núñez V, Bachert C, Mullol J. Rupatadine: global safety evaluation in allergic rhinitis and urticaria. Expert Opin Drug Saf. 2016 Oct;15(10):1439-48. doi: 10.1080/14740338.2016.1221399. Epub 2016 Aug 19. PMID: 27500993.

3: Mullol J, Bousquet J, Bachert C, Canonica GW, Giménez-Arnau A, Kowalski ML, Simons FE, Maurer M, Ryan D, Scadding G. Update on rupatadine in the management of allergic disorders. Allergy. 2015 Jan;70 Suppl 100:1-24. doi: 10.1111/all.12531. PMID: 25491409.

4: Kaur M, Jasinski JP, Luopa ZA, Kumar N, Patel NG, Gudaparthi O, Yathirajan HS. Rupatadine. Acta Crystallogr Sect E Struct Rep Online. 2013 May 31;69(Pt 6):o980. doi: 10.1107/S1600536813014256. PMID: 23795133; PMCID: PMC3685114.

5: Hide M, Hirata K, Komorita N, Kubo H, Suzuki T, Tanaka A, Aoki H. [USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS]. Arerugi. 2020;69(3):174-183. Japanese. doi: 10.15036/arerugi.69.174. PMID: 32435018.

6: Keam SJ, Plosker GL. Rupatadine: a review of its use in the management of allergic disorders. Drugs. 2007;67(3):457-74. doi: 10.2165/00003495-200767030-00008. PMID: 17335300.

7: Shamizadeh S, Brockow K, Ring J. Rupatadine: efficacy and safety of a non- sedating antihistamine with PAF-antagonist effects. Allergo J Int. 2014;23(3):87-95. doi: 10.1007/s40629-014-0011-7. Epub 2014 May 9. PMID: 26120520; PMCID: PMC4479428.

8: Valero A, Izquierdo I, Kowalski ML, Scadding GK, Bousquet J, Mullol J. Higher efficacy of rupatadine 20 mg and 10 mg versus placebo in patients with perennial allergic rhinitis: a pooled responder analysis. Allergy Asthma Clin Immunol. 2020 Apr 23;16:29. doi: 10.1186/s13223-020-00425-1. PMID: 32346387; PMCID: PMC7181536.

9: Mullol J, Bousquet J, Bachert C, Canonica WG, Gimenez-Arnau A, Kowalski ML, Martí-Guadaño E, Maurer M, Picado C, Scadding G, Van Cauwenberge P. Rupatadine in allergic rhinitis and chronic urticaria. Allergy. 2008 Apr;63 Suppl 87:5-28. doi: 10.1111/j.1398-9995.2008.01640.x. PMID: 18339040.

10: Picado C. Rupatadine: pharmacological profile and its use in the treatment of allergic disorders. Expert Opin Pharmacother. 2006 Oct;7(14):1989-2001. doi: 10.1517/14656566.7.14.1989. PMID: 17020424.

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