Methenamine borate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577261

CAS#: 27401-86-1

Description: Methenamine borate is an anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH.

Chemical Structure

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Methenamine borate
CAS# 27401-86-1
Instruction

Theoretical Analysis

MedKoo Cat#: 577261
Name: Methenamine borate
CAS#: 27401-86-1
Chemical Formula: C6H15BN4O3
Exact Mass: 202.12
Molecular Weight: 202.020
Elemental Analysis: C, 35.67; H, 7.48; B, 5.35; N, 27.73; O, 23.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Borohexamine; Methenamine borate; Urotropin borate

IUPAC/Chemical Name: 1,3,5,7-tetraazaadamantane borate

InChi Key: MWWHVOZLSBBRDS-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H12N4.BH3O3/c1-7-2-9-4-8(1)5-10(3-7)6-9;2-1(3)4/h1-6H2;2-4H

SMILES Code: OB(O)O.C1N2CN3CN(CN1C3)C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 202.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Barclay J, Veeratterapillay R, Harding C. Non-antibiotic options for recurrent urinary tract infections in women. BMJ. 2017 Nov 23;359:j5193. doi: 10.1136/bmj.j5193. PubMed PMID: 29170359.

2: Zhang L, Hao W, Xu L, Gao Y, Wang X, Zhu D, Chen Z, Zhang X, Chen H, Mei L. A pH-sensitive methenamine mandelate-loaded nanoparticle induces DNA damage and apoptosis of cancer cells. Acta Biomater. 2017 Oct 15;62:246-256. doi: 10.1016/j.actbio.2017.08.019. Epub 2017 Aug 16. PubMed PMID: 28822844.

3: Yang M, Tang Y. [Application of three methods of periodic acid-silver-methenamine staining in renal biopsy]. Zhonghua Bing Li Xue Za Zhi. 2017 Jun 8;46(6):419-420. doi: 10.3760/cma.j.issn.0529-5807.2017.06.013. Chinese. PubMed PMID: 28591993.

4: Lo TS, Hammer KD, Zegarra M, Cho WC. Methenamine: a forgotten drug for preventing recurrent urinary tract infection in a multidrug resistance era. Expert Rev Anti Infect Ther. 2014 May;12(5):549-54. doi: 10.1586/14787210.2014.904202. Epub 2014 Apr 1. Review. PubMed PMID: 24689705.