Octenidine saccharin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414539

CAS#: 86767-75-1 (saccharin)

Description: Octenidine saccharin is a Dental Plaque Inhibitor

Chemical Structure

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Octenidine saccharin
CAS# 86767-75-1 (saccharin)
Instruction

Theoretical Analysis

MedKoo Cat#: 414539
Name: Octenidine saccharin
CAS#: 86767-75-1 (saccharin)
Chemical Formula: C50H72N6O6S2
Exact Mass: 916.50
Molecular Weight: 917.280
Elemental Analysis: C, 65.47; H, 7.91; N, 9.16; O, 10.47; S, 6.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 86767-75-1 (saccharin); 71251-02-0 (free base); 70775-75-6 (2HCl)  

Synonym: Octenidine saccharin; Win41,464-6; Win-41,464-6; Win 41,464-6

IUPAC/Chemical Name: 1-Octanamine, N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, compound with 1,2-benzisothiazol-3(2H)-one 1,1-dioxide (1:2)

InChi Key: OBHFLBIBWSFADO-UHFFFAOYSA-N

InChi Code: InChI=1S/C36H62N4.2C7H5NO3S/c1-3-5-7-9-15-19-27-37-35-23-31-39(32-24-35)29-21-17-13-11-12-14-18-22-30-40-33-25-36(26-34-40)38-28-20-16-10-8-6-4-2;2*9-7-5-3-1-2-4-6(5)12(10,11)8-7/h23-26,31-34H,3-22,27-30H2,1-2H3;2*1-4H,(H,8,9)

SMILES Code: CCCCCCCC/N=C1C=CN(CCCCCCCCCCN(C=C/2)C=CC2=N/CCCCCCCC)C=C/1.O=C(C3=C4C=CC=C3)NS4(=O)=O.O=C(C5=C6C=CC=C5)NS6(=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 917.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Assadian O. Octenidine dihydrochloride: chemical characteristics and antimicrobial properties. J Wound Care. 2016 Mar;25(3 Suppl):S3-6. doi: 10.12968/jowc.2016.25.Sup3.S3. PMID: 26949863.

2: Hübner NO, Siebert J, Kramer A. Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol Physiol. 2010;23(5):244-58. doi: 10.1159/000314699. Epub 2010 May 18. PMID: 20484966.

3: Lopez KM, Hobden JA, Warner IM. Octenidine/carbenicillin GUMBOS as potential treatment for oropharyngeal gonorrhoea. J Antimicrob Chemother. 2020 Dec 1;75(12):3576-3581. doi: 10.1093/jac/dkaa346. PMID: 32830243.

4: Clanner-Engelshofen BM, French LE, Reinholz M. Octenidine disinfection during the SARS-CoV-2 pandemia. Eur J Dermatol. 2020 Oct 1;30(5):613-614. doi: 10.1684/ejd.2020.3856. PMID: 32972908; PMCID: PMC8120489.

5: Yakuschenko IK, Pozdeeva NN, Mumyatova VA, Terentiev AA, Gadomsky SY. Iso- octenidine: Promising Octenidine Analogue with Improved Solubility. Curr Org Synth. 2020 Dec 30. doi: 10.2174/1570179417666201231104453. Epub ahead of print. PMID: 33390116.

6: Shepherd MJ, Moore G, Wand ME, Sutton JM, Bock LJ. Pseudomonas aeruginosa adapts to octenidine in the laboratory and a simulated clinical setting, leading to increased tolerance to chlorhexidine and other biocides. J Hosp Infect. 2018 Nov;100(3):e23-e29. doi: 10.1016/j.jhin.2018.03.037. Epub 2018 Mar 31. PMID: 29614247.

7: Szostak K, Czogalla A, Przybyło M, Langner M. New lipid formulation of octenidine dihydrochloride. J Liposome Res. 2018 Jun;28(2):106-111. doi: 10.1080/08982104.2016.1275678. Epub 2017 Jan 18. PMID: 28006995.

8: Melhorn S, Staubach P. Octenidindihydrochlorid : Das Antiseptikum, das nicht jede Grundlage mag [Octenidine dihydrochloride : The antiseptic that does not like every base formulation]. Hautarzt. 2018 May;69(5):427-429. German. doi: 10.1007/s00105-018-4139-0. PMID: 29532135.

9: Htun HL, Hon PY, Holden MTG, Ang B, Chow A. Chlorhexidine and octenidine use, carriage of qac genes, and reduced antiseptic susceptibility in methicillin- resistant Staphylococcus aureus isolates from a healthcare network. Clin Microbiol Infect. 2019 Sep;25(9):1154.e1-1154.e7. doi: 10.1016/j.cmi.2018.12.036. Epub 2019 Jan 6. PMID: 30625411.

10: Daeschlein G. Antimicrobial and antiseptic strategies in wound management. Int Wound J. 2013 Dec;10 Suppl 1(Suppl 1):9-14. doi: 10.1111/iwj.12175. PMID: 24251838; PMCID: PMC7950476.