Npc 12626

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414510

CAS#: 117571-54-7

Description: Npc 12626 is a N-methyl-D-aspartate receptor antagonist; NPC 17742, the (2R,4R,5S)-isomer, is the most potent isomer in the mixture NPC 12626.

Chemical Structure

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Npc 12626
CAS# 117571-54-7
Instruction

Theoretical Analysis

MedKoo Cat#: 414510
Name: Npc 12626
CAS#: 117571-54-7
Chemical Formula: C11H22NO5P
Exact Mass: 279.12
Molecular Weight: 279.270
Elemental Analysis: C, 47.31; H, 7.94; N, 5.02; O, 28.64; P, 11.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Npc 12626; Npc12626; Npc-12626

IUPAC/Chemical Name: Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)-

InChi Key: DHJQWBSZKBDBFP-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H22NO5P/c12-10(11(13)14)7-9-4-2-1-3-8(9)5-6-18(15,16)17/h8-10H,1-7,12H2,(H,13,14)(H2,15,16,17)

SMILES Code: O=C(O)C(N)CC1C(CCP(O)(O)=O)CCCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 279.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bobelis DJ, Balster RL. Pharmacological specificity of the discriminative stimulus properties of 2-amino-4,5-(1,2-cyclohexyl)-7-phosphono-heptanoic acid (NPC 12626), a competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1993 Feb;264(2):845-53. PMID: 8437128.

2: Willetts J, Bobelis DJ, Balster RL. Drug discrimination based on the competitive N-methyl-D-aspartate antagonist, NPC 12626. Psychopharmacology (Berl). 1989;99(4):458-62. doi: 10.1007/BF00589892. PMID: 2687923.

3: Walker DL, Gold PE. Effects of the novel NMDA antagonist, NPC 12626, on long- term potentiation, learning and memory. Brain Res. 1991 May 24;549(2):213-21. doi: 10.1016/0006-8993(91)90460-d. PMID: 1832074.

4: Kavaliers M, Choleris E, Saucier DM. The NMDA receptor antagonist, NPC 12626, reduces the pronociceptive effects of orphanin FQ and kappa opiate antinociception in the land snail, Cepaea nemoralis. Peptides. 1997;18(7):943-7. doi: 10.1016/s0196-9781(97)00037-5. PMID: 9357050.

5: Ferkany JW, Kyle DJ, Willets J, Rzeszotarski WJ, Guzewska ME, Ellenberger SR, Jones SM, Sacaan AI, Snell LD, Borosky S, et al. Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist. J Pharmacol Exp Ther. 1989 Jul;250(1):100-9. PMID: 2545856.

6: Ferkany JW, Kyle DJ, Rzeszotarski WJ. NPC 12626, a novel, competitive NMDA antagonist: pharmacological and toxicological profile. Prog Clin Biol Res. 1990;361:525-32. PMID: 2290850.

7: Saucier DM, Kavaliers M. Antagonistic effects of the selective, competitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPC 12626, on kappa opiate- induced analgesia in male deer mice. Brain Res. 1994 Feb 21;637(1-2):292-6. doi: 10.1016/0006-8993(94)91247-5. PMID: 8180809.

8: Gold LH, Balster RL. Effects of NMDA receptor antagonists in squirrel monkeys trained to discriminate the competitive NMDA receptor antagonist NPC 12626 from saline. Eur J Pharmacol. 1993 Jan 19;230(3):285-92. doi: 10.1016/0014-2999(93)90563-w. PMID: 8095022.

9: Willetts J, Clissold DB, Hartman TL, Brandsgaard RR, Hamilton GS, Ferkany JW. Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist. J Pharmacol Exp Ther. 1993 Jun;265(3):1055-62. PMID: 8099615.

10: Vogel MW, Prittie J. Purkinje cell dendritic arbors in chick embryos following chronic treatment with an N-methyl-D-aspartate receptor antagonist. J Neurobiol. 1995 Apr;26(4):537-52. doi: 10.1002/neu.480260407. PMID: 7602317.