Ciprofloxacin HCl monohydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 577081

CAS#: 86393-32-0

Description: Ciprofloxacin HCl monohydrate is a broad-spectrum antimicrobial carboxyfluoroquinoline.

Chemical Structure

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Ciprofloxacin HCl monohydrate
CAS# 86393-32-0
Instruction

Theoretical Analysis

MedKoo Cat#: 577081
Name: Ciprofloxacin HCl monohydrate
CAS#: 86393-32-0
Chemical Formula: C17H21ClFN3O4
Exact Mass: 385.12
Molecular Weight: 385.820
Elemental Analysis: C, 52.92; H, 5.49; Cl, 9.19; F, 4.92; N, 10.89; O, 16.59

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ciprofloxacin hydrochloride monohydrate; Ciprofloxacin HCl monohydrate

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, monohydrochloride, monohydrate

InChi Key: ARPUHYJMCVWYCZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2

SMILES Code: O.Cl.OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Okoye NV, Oyawole MR, Uzochukwu PU, Oyetunde OO. Review of ciprofloxacin use in children. Nig Q J Hosp Med. 2013 Jan-Mar;23(1):43-7. Review. PubMed PMID: 24579494.

2: Kaplan YC, Koren G. Use of ciprofloxacin during breastfeeding. Can Fam Physician. 2015 Apr;61(4):343-4. Review. PubMed PMID: 26052598; PubMed Central PMCID: PMC4396759.

3: Justo JA, Danziger LH, Gotfried MH. Efficacy of inhaled ciprofloxacin in the management of non-cystic fibrosis bronchiectasis. Ther Adv Respir Dis. 2013 Oct;7(5):272-87. doi: 10.1177/1753465813487412. Epub 2013 May 20. Review. PubMed PMID: 23690368.

4: Samarei R. Comparison of local and systemic ciprofloxacin ototoxicity in the treatment of chronic media otitis. Glob J Health Sci. 2014 Sep 18;6(7 Spec No):144-9. doi: 10.5539/gjhs.v6n7p144. PubMed PMID: 25363170; PubMed Central PMCID: PMC4796472.

5: Du J, El-Sherbiny IM, Smyth HD. Swellable ciprofloxacin-loaded nano-in-micro hydrogel particles for local lung drug delivery. AAPS PharmSciTech. 2014 Dec;15(6):1535-44. doi: 10.1208/s12249-014-0176-x. Epub 2014 Jul 31. PubMed PMID: 25079240; PubMed Central PMCID: PMC4245439.