MRIA9
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MedKoo CAT#: 464782

CAS#: 2750707-05-0

Description: MRIA9 is a Selective Salt-Inducible Kinase Inhibitor. MRIA9 showed dual SIK/PAK activity and excellent selectivity over other kinases. MRIA9 sensitizes ovarian cancer cells to treatment with the mitotic agent paclitaxel, confirming earlier data from genetic knockdown studies and suggesting a combination therapy with SIK inhibitors and paclitaxel for the treatment of paclitaxel-resistant ovarian cancer.

Chemical Structure

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MRIA9
CAS# 2750707-05-0
Instruction

Theoretical Analysis

MedKoo Cat#: 464782
Name: MRIA9
CAS#: 2750707-05-0
Chemical Formula: C24H22ClFN6O3
Exact Mass: 496.14
Molecular Weight: 496.927
Elemental Analysis: C, 58.01; H, 4.46; Cl, 7.13; F, 3.82; N, 16.91; O, 9.66

Price and Availability

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5mg USD 1250 2 Weeks
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Synonym: MRIA9; MRIA 9; MRIA-9;

IUPAC/Chemical Name: 8-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(3-fluoropyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one

InChi Key: QKNBRNSGPNCARD-SGNKCFNYSA-N

InChi Code: InChI=1S/C24H22ClFN6O3/c1-28-24-30-9-14-7-17(16-5-4-13(8-18(16)25)21-19(26)3-2-6-29-21)23(33)32(22(14)31-24)10-20-34-11-15(27)12-35-20/h2-9,15,20H,10-12,27H2,1H3,(H,28,30,31)/t15-,20-

SMILES Code: O=C1C(C2=CC=C(C3=NC=CC=C3F)C=C2Cl)=CC4=CN=C(NC)N=C4N1C[C@H]5OC[C@H](N)CO5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 496.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S. Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. J Med Chem. 2021 Jun 4. doi: 10.1021/acs.jmedchem.0c02144. Epub ahead of print. PMID: 34086472.