MCB-3837 sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576928

CAS#: 856676-92-1

Description: MCB-3837 sodium is an oxazolidinone-quinolone hybrid molecule with antibacterial activity.

Chemical Structure

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MCB-3837 sodium
CAS# 856676-92-1
Instruction

Theoretical Analysis

MedKoo Cat#: 576928
Name: MCB-3837 sodium
CAS#: 856676-92-1
Chemical Formula: C31H32F2N4NaO11P
Exact Mass: 728.17
Molecular Weight: 728.570
Elemental Analysis: C, 51.11; H, 4.43; F, 5.22; N, 7.69; Na, 3.16; O, 24.16; P, 4.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MCB-3837 sodium; MCB 3837 sodium; MCB3837 sodium

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 7-(4-((4-((5S)-5-((acetylamino)methyl)-2-oxo-3-oxazolidinyl)-2-fluorophenoxy)methyl)-4-(phosphonooxy)-1-piperidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, sodium salt

InChi Key: YJXYMDNRYHCPHB-BDQAORGHSA-M

InChi Code: InChI=1S/C31H33F2N4O11P.Na/c1-17(38)34-13-20-14-37(30(42)47-20)19-4-5-27(24(33)10-19)46-16-31(48-49(43,44)45)6-8-35(9-7-31)26-12-25-21(11-23(26)32)28(39)22(29(40)41)15-36(25)18-2-3-18;/h4-5,10-12,15,18,20H,2-3,6-9,13-14,16H2,1H3,(H,34,38)(H,40,41)(H2,43,44,45);/q;+1/p-1/t20-;/m0./s1

SMILES Code: [Na+].CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(OCC3(CCN(CC3)c4cc5N(C=C(C(=O)O)C(=O)c5cc4F)C6CC6)OP(=O)(O)[O-])c(F)c2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 728.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Rashid MU, Dalhoff A, Bäckström T, Björkhem-Bergman L, Panagiotidis G, Weintraub A, Nord CE. Ecological impact of MCB3837 on the normal human microbiota. Int J Antimicrob Agents. 2014 Aug;44(2):125-30. doi: 10.1016/j.ijantimicag.2014.03.016. Epub 2014 May 23. PMID: 24931053.

2. Dalhoff A, Rashid MU, Kapsner T, Panagiotidis G, Weintraub A, Nord CE. Analysis of effects of MCB3681, the antibacterially active substance of prodrug MCB3837, on human resident microflora as proof of principle. Clin Microbiol Infect. 2015 Aug;21(8):767.e1-4. doi: 10.1016/j.cmi.2015.05.025. Epub 2015 Jun 3. PMID: 26047854.