Cyclosporine A acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111007

CAS#: 83602-41-9

Description: Cyclosporin A Acetate is a non-immunosuppressive analog of Cyclosporin A, which is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the immune system and risk of organ rejection.

Chemical Structure

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Cyclosporine A acetate
CAS# 83602-41-9
Instruction

Theoretical Analysis

MedKoo Cat#: 111007
Name: Cyclosporine A acetate
CAS#: 83602-41-9
Chemical Formula: C64H113N11O13
Exact Mass: 1,243.85
Molecular Weight: 1,244.672
Elemental Analysis: C, 61.76; H, 9.15; N, 12.38; O, 16.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: B3-243; Cyclosporine A acetate; O-Acetyl C(9) cyclosporin A; OACsA; Sdz-33-243; B3243; B3 243; Cyclosporine A acetate

IUPAC/Chemical Name: Cyclosporin A, 6-acetate

InChi Key: SNGZGZKWJAWNLP-BRPCFJBISA-N

InChi Code: InChI=1S/C64H113N11O13/c1-26-28-29-41(15)53(88-44(18)76)52-57(81)67-45(27-2)59(83)70(20)34-49(77)71(21)47(31-36(5)6)56(80)69-50(39(11)12)61(85)72(22)48(32-37(7)8)55(79)65-42(16)54(78)66-43(17)58(82)75(25)64(19,33-38(9)10)63(87)68-46(30-35(3)4)60(84)73(23)51(40(13)14)62(86)74(52)24/h26,28,35-43,45-48,50-53H,27,29-34H2,1-25H3,(H,65,79)(H,66,78)(H,67,81)(H,68,87)(H,69,80)/b28-26+/t41-,42+,43-,45+,46+,47+,48+,50+,51+,52+,53-,64+/m1/s1

SMILES Code: CC[C@@H]1NC(=O)[C@H]([C@H](OC(=O)C)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,244.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Tamai I, Safa AR. Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells. J Biol Chem. 1991 Sep 5;266(25):16796-800. PMID: 1679434.

2. Tullberg-Reinert H, Hefti AF. Different inhibitory actions of cyclosporine A and cyclosporine A-acetate on lipopolysaccharide-, interleukin 1-, 1,25 dihydroxyvitamin D3- and parathyroid hormone-stimulated calcium and lysosomal enzyme release from mouse calvaria in vitro. Agents Actions. 1991 Mar;32(3-4):321-32. doi: 10.1007/BF01980893. PMID: 1862749.

3. Tamai I, Safa AR. Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. J Biol Chem. 1990 Sep 25;265(27):16509-13. PMID: 1975813.