Quipazine maleate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559303

CAS#: 5786-68-5

Description: Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. Like quipazine, quipazine derivatives produce contracture of smooth muscle organs and bronchospasm.

Chemical Structure

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Quipazine maleate
CAS# 5786-68-5
Instruction

Theoretical Analysis

MedKoo Cat#: 559303
Name: Quipazine maleate
CAS#: 5786-68-5
Chemical Formula: C17H19N3O4
Exact Mass: 0.00
Molecular Weight: 329.360
Elemental Analysis: C, 62.00; H, 5.81; N, 12.76; O, 19.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Quipazine maleate; MA 1291; MA1291; MA-1291

IUPAC/Chemical Name: 2-(1-Piperazinyl)quinoline maleate

InChi Key: QYJJDHZHSCTBII-BTJKTKAUSA-N

InChi Code: InChI=1S/C13H15N3.C4H4O4/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16;5-3(6)1-2-4(7)8/h1-6,14H,7-10H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: OC(/C=C\C(O)=O)=O.N1(c(cc2)nc3c2cccc3)CCNCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 329.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Trubitsyna TK, Kashkovskiĭ MD. Farmakologicheskie svoĭstva nekotorykh indolilakil'nykh proizvodnykh kvipazina [Pharmacological properties of indolylalkyl derivatives of quipazine]. Farmakol Toksikol. 1980 Sep-Oct;43(5):530-6. Russian. PMID: 7449980.

Liu Y, Zhang ZY. Serotonin receptor agonist quipazine promotes proliferation and apoptosis of human hepatocyte strain of L-02 strain. Hepatobiliary Pancreat Dis Int. 2009 Jun;8(3):278-81. PMID: 19502168.

Bergé-Laval V, Gestreau C. Quipazine Elicits Swallowing in the Arterially Perfused Rat Preparation: A Role for Medullary Raphe Nuclei? Int J Mol Sci. 2020 Jul 20;21(14):5120. doi: 10.3390/ijms21145120. PMID: 32698469; PMCID: PMC7404031.