Irindalone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576763

CAS#: 96478-43-2

Description: Irindalone is an S2-serotonergic antagonist.

Chemical Structure

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Irindalone
CAS# 96478-43-2
Instruction

Theoretical Analysis

MedKoo Cat#: 576763
Name: Irindalone
CAS#: 96478-43-2
Chemical Formula: C24H29FN4O
Exact Mass: 408.23
Molecular Weight: 408.520
Elemental Analysis: C, 70.56; H, 7.16; F, 4.65; N, 13.71; O, 3.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Irindalone

IUPAC/Chemical Name: (+)-(1R,3S)-1-(2-(4-(3-(p-Fluorophenyl)-1-indanyl)-1-piperazinyl)ethyl)-2-imidazolidinone

InChi Key: GHAMYXPEZSUOCU-XZOQPEGZSA-N

InChi Code: InChI=1S/C24H29FN4O/c25-19-7-5-18(6-8-19)22-17-23(21-4-2-1-3-20(21)22)28-14-11-27(12-15-28)13-16-29-10-9-26-24(29)30/h1-8,22-23H,9-17H2,(H,26,30)/t22-,23+/m0/s1

SMILES Code: Fc1ccc(cc1)[C@@H]2C[C@@H](N3CCN(CCN4CCNC4=O)CC3)c5ccccc25

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 408.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Gradin K, Carlsson S, Hedner T, Persson B. Cardiovascular effects of irindalone, a new S2-serotonergic antagonist, in the rat. Pharmacol Toxicol. 1990 Sep;67(3):199-204. doi: 10.1111/j.1600-0773.1990.tb00813.x. PMID: 2255675.

2. Gradin K, Hedner T, Persson B. Antihypertensive effects of chronic 5-hydroxytryptamine (5-HT2) receptor blockade with irindalone in the spontaneously hypertensive rat. J Neural Transm Gen Sect. 1991;83(3):227-33. doi: 10.1007/BF01253392. PMID: 1674420.

3. Mikkelsen EO, Nyborg NC, Jensen KT, Boeck V. Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. Eur J Pharmacol. 1988 Apr 27;149(1-2):145-8. doi: 10.1016/0014-2999(88)90053-2. PMID: 3396624.