PDD4091 | CAS#1373651-41-2 | G6PD inhibitor

PDD4091
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464622

CAS#: 1373651-41-2

Description: PDD4091 is a novel G6PD inhibitor.

Chemical Structure

PDD4091

CAS# 1373651-41-2

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 464622
Name: PDD4091
CAS#: 1373651-41-2
Chemical Formula: C19H32N2O3S
Exact Mass: 368.21
Molecular Weight: 368.540
Elemental Analysis: C, 61.92; H, 8.75; N, 7.60; O, 13.02; S, 8.70

Price and Availability

Size	Price	Availability
1mg	USD 95	Ready to ship
5mg	USD 350	Ready to ship
10mg	USD 550	Ready to ship
25mg	USD 950	Ready to ship
50mg	USD 1650	Ready to ship
100mg	USD 2950	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 1373651-41-2,

Synonym: PDD4091; PDD 4091; PDD-4091

IUPAC/Chemical Name: N-[(3beta,5alpha)-17-Oxoandrostan-3-yl]sulfamide

InChi Key: QLIJDTTVUNSTPX-LUJOEAJASA-N

InChi Code: InChI=1S/C19H32N2O3S/c1-18-9-7-13(21-25(20,23)24)11-12(18)3-4-14-15-5-6-17(22)19(15,2)10-8-16(14)18/h12-16,21H,3-11H2,1-2H3,(H2,20,23,24)/t12-,13-,14-,15-,16-,18-,19-/m0/s1

SMILES Code: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(=O)CC4)[H])(CC[C@]1(C[C@@H](NS(N)(=O)=O)CC2)[H])[H])[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#S23S08C29

QC Data:

View QC data: current batch, Lot#S23S08C29

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	PDD4091 had a reasonably wide therapeutic window (0.01–15 mg kg-1 day-1) with an EC50 of 0.26 +/- 0.10, and 0.58 +/-0.36 mg kg-1 day-1 reduced both RVSP and RVEDP.
In vitro activity:	To be determined
In vivo activity:	PDD4091 dose-dependently relaxed PA precontracted with KCl. PDD4091 arrested maladaptive gene expression in vascular cells of the PA wall, reduced cell growth in occlusive pulmonary arterial disease, and dose-dependently relaxed precontracted PAs. Reference: J Pharmacol Exp Ther. May 1, 2021, 377 (2) 284-292 https://jpet.aspetjournals.org/content/377/2/284

Preparing Stock Solutions

The following data is based on the product molecular weight 368.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Atsushi Kitagawa, Christina Jacob, Allan Jordan, Ian Waddell, Ivan F. McMurtry and Sachin A. Gupte. Journal of Pharmacology and Experimental Therapeutics May 1, 2021, 377 (2) 284-292; DOI: https://doi.org/10.1124/jpet.120.000166
In vitro protocol:	To be determined
In vivo protocol:	1. Atsushi Kitagawa, Christina Jacob, Allan Jordan, Ian Waddell, Ivan F. McMurtry and Sachin A. Gupte. Journal of Pharmacology and Experimental Therapeutics May 1, 2021, 377 (2) 284-292; DOI: https://doi.org/10.1124/jpet.120.000166

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1. Atsushi Kitagawa, Christina Jacob, Allan Jordan, Ian Waddell, Ivan F. McMurtry and Sachin A. Gupte. Journal of Pharmacology and Experimental Therapeutics May 1, 2021, 377 (2) 284-292; DOI: https://doi.org/10.1124/jpet.120.000166

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