ABEA-BY630

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464598

CAS#: unknown

Description: ABEA-BY630 is a novel fluorescent A3 adenosine receptor (A3‐AR) agonist.

Chemical Structure

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ABEA-BY630
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 464598
Name: ABEA-BY630
CAS#: unknown
Chemical Formula: C45H51BF2N10O7S
Exact Mass: 924.37
Molecular Weight: 924.833
Elemental Analysis: C, 58.44; H, 5.56; B, 1.17; F, 4.11; N, 15.15; O, 12.11; S, 3.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ABEA-BY630; ABEABY630; ABEA BY630; ABEA-X-BY630; ABEA X BY630; ABEAXBY630;

IUPAC/Chemical Name: (2S,3S,4R,5R)-5-(6-((4-(6-(2-(4-((E)-2-(5,5-difluoro-7-(thiophen-2-yl)-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)vinyl)phenoxy)acetamido)hexanamido)butyl)amino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide

InChi Key: LODSCYWXMGXOOZ-ZQJYZEHFSA-N

InChi Code: InChI=1S/C45H51BF2N10O7S/c1-2-49-44(63)41-39(61)40(62)45(65-41)56-28-55-38-42(53-27-54-43(38)56)52-23-7-6-22-50-36(59)10-4-3-5-21-51-37(60)26-64-33-18-12-29(13-19-33)11-14-30-15-16-31-25-32-17-20-34(35-9-8-24-66-35)58(32)46(47,48)57(30)31/h8-9,11-20,24-25,27-28,39-41,45,61-62H,2-7,10,21-23,26H2,1H3,(H,49,63)(H,50,59)(H,51,60)(H,52,53,54)/b14-11+/t39-,40+,41-,45+/m0/s1

SMILES Code: O=C([C@H]1O[C@@H](N2C=NC3=C(NCCCCNC(CCCCCNC(COC4=CC=C(/C=C/C5=[N+](C(C=C5)=C6)B(F)(F)[N-]7C6=CC=C7C8=CC=CS8)C=C4)=O)=O)N=CN=C23)[C@H](O)[C@@H]1O)NCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 924.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Stoddart LA, Kilpatrick LE, Corriden R, Kellam B, Briddon SJ, Hill SJ. Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A3 receptor. FASEB J. 2021 Apr;35(4):e21211. doi: 10.1096/fj.202001729RR. PMID: 33710641.

2: Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ. Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist. Neuropharmacology. 2015 Nov;98:68-77. doi: 10.1016/j.neuropharm.2015.04.013. Epub 2015 Apr 30. PMID: 25937210.

3: Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ. Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J. 2008 Mar;22(3):850-60. doi: 10.1096/fj.07-8180com. Epub 2007 Oct 24. PMID: 17959910.