PBI-4DNJ-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464583

CAS#: unknown

Description: PBI-4DNJ-1 is a glycosidase inhibitor. PBI-4DNJ-1 exhibited positional isomeric effects on the optical properties, glycosidase inhibition activity, and hypoglycemic effects. PBI-4DNJ-1 exhibited potent hypoglycemic effects in mice, with 41.33 ± 2.84 and 37.45 ± 3.94% decreases in blood glucose at 15 and 30 min,

Chemical Structure

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PBI-4DNJ-1
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 464583
Name: PBI-4DNJ-1
CAS#: unknown
Chemical Formula: C84H96N18O26
Exact Mass: 1,772.67
Molecular Weight: 1,773.792
Elemental Analysis: C, 56.88; H, 5.46; N, 14.21; O, 23.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PBI-4DNJ-1; PBI4DNJ-1; PBI 4DNJ-1; PBI-4DNJ1; PBI-4DNJ 1; PBI4DNJ1; PBI 4DNJ 1;

IUPAC/Chemical Name: 5,13-di(l1-oxidanyl)-6,12-bis(4-((1-(3-((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methoxy)phenoxy)-2,9-bis((1-(3-((2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)anthra[2,1,9-def:6,5,10-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone

InChi Key: YZBSGWYWMOAYRH-XWAPBGMNSA-N

InChi Code: InChI=1S/C84H96N18O26/c103-35-53-73(113)77(117)59(109)31-93(53)13-1-17-97-25-41(85-89-97)29-101-81(121)49-21-57(107)67-69-63(127-47-9-5-45(6-10-47)125-39-43-27-99(91-87-43)19-3-15-95-33-61(111)79(119)75(115)55(95)37-105)23-51-66-52(84(124)102(83(51)123)30-42-26-98(90-86-42)18-2-14-94-32-60(110)78(118)74(114)54(94)36-104)24-64(70(72(66)69)68-58(108)22-50(82(101)122)65(49)71(67)68)128-48-11-7-46(8-12-48)126-40-44-28-100(92-88-44)20-4-16-96-34-62(112)80(120)76(116)56(96)38-106/h5-12,21-28,53-56,59-62,73-80,103-106,109-120H,1-4,13-20,29-40H2/t53-,54-,55-,56-,59+,60+,61+,62+,73-,74-,75-,76-,77-,78-,79-,80-/m1/s1

SMILES Code: [O]C1=C(C2=C3C([O])=CC4=C2C(C(N(CC5=CN(CCCN6C[C@H](O)[C@@H](O)[C@H](O)[C@H]6CO)N=N5)C4=O)=O)=C1)C7=C(OC8=CC=C(OCC9=CN(CCCN%10C[C@H](O)[C@@H](O)[C@H](O)[C@H]%10CO)N=N9)C=C8)C=C%11C%12=C(C(N(CC%13=CN(CCCN%14C[C@H](O)[C@@H](O)[C@H](O)[C@H]%14CO)N=N%13)C%11=O)=O)C=C(OC%15=CC=C(OCC%16=CN(CCCN%17C[C@H](O)[C@@H](O)[C@H](O)[C@H]%17CO)N=N%16)C=C%15)C3=C7%12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,773.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li RF, Yang JX, Liu J, Ai GM, Zhang HY, Xu LY, Chen SB, Zhang HX, Li XL, Cao ZR, Wang KR. Positional Isomeric Effects on the Optical Properties, Multivalent Glycosidase Inhibition Effect, and Hypoglycemic Effect of Perylene Bisimide- deoxynojirimycin Conjugates. J Med Chem. 2021 Apr 22. doi: 10.1021/acs.jmedchem.1c00036. Epub ahead of print. PMID: 33886333.