Imidaprilat

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576634

CAS#: 89371-44-8

Description: Imidaprilat is an angiotensin-converting enzyme inhibitor that has been shown to inhibit matrix metalloproteinase-2 (MMP-2) activity in human cardiac fibroblasts.


Chemical Structure

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Imidaprilat
CAS# 89371-44-8

Theoretical Analysis

MedKoo Cat#: 576634
Name: Imidaprilat
CAS#: 89371-44-8
Chemical Formula: C18H23N3O6
Exact Mass: 377.16
Molecular Weight: 377.400
Elemental Analysis: C, 57.29; H, 6.14; N, 11.13; O, 25.44

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Imidaprilat

IUPAC/Chemical Name: (4S)-3-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-1-methyl-2-oxo-4-imidazolidinecarboxylic acid

InChi Key: VFAVNRVDTAPBNR-UBHSHLNASA-N

InChi Code: InChI=1S/C18H23N3O6/c1-11(15(22)21-14(17(25)26)10-20(2)18(21)27)19-13(16(23)24)9-8-12-6-4-3-5-7-12/h3-7,11,13-14,19H,8-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,13-,14-/m0/s1

SMILES Code: C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2[C@@H](CN(C)C2=O)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 377.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Guo XG, Uzui H, Mizuguchi T, Ueda T, Chen JZ, Lee JD. Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1beta via NO-dependent pathway. Int J Cardiol. 2008 Jun 6;126(3):414-20. doi: 10.1016/j.ijcard.2007.08.134. Epub 2008 Jan 14. PMID: 18192036.

2. Obata T. Imidaprilat suppresses nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum. Neurosci Res. 2006 Mar;54(3):192-6. doi: 10.1016/j.neures.2005.11.007. Epub 2006 Jan 4. PMID: 16386813.

3. Obata T. Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum. Brain Res. 2006 Feb 3;1071(1):250-3. doi: 10.1016/j.brainres.2005.11.100. Epub 2006 Jan 9. PMID: 16406270.