Pipotiazine palmitate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576600

CAS#: 37517-26-3

Description: Pipotiazine palmitate is a member of phenothiazine family of tranquilizing agents.

Chemical Structure

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Pipotiazine palmitate
CAS# 37517-26-3
Instruction

Theoretical Analysis

MedKoo Cat#: 576600
Name: Pipotiazine palmitate
CAS#: 37517-26-3
Chemical Formula: C40H63N3O4S2
Exact Mass: 713.43
Molecular Weight: 714.080
Elemental Analysis: C, 67.28; H, 8.89; N, 5.88; O, 8.96; S, 8.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Pipotiazine palmitate

IUPAC/Chemical Name: Hexadecanoic acid, 2-(1-(3-(2-((dimethylamino)sulfonyl)-10H-phenothiazin-10-yl)propyl)-4-piperidinyl)ethyl ester

InChi Key: KTOYYUONFQWSMW-UHFFFAOYSA-N

InChi Code: InChI=1S/C40H63N3O4S2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-22-40(44)47-32-27-34-25-30-42(31-26-34)28-19-29-43-36-20-17-18-21-38(36)48-39-24-23-35(33-37(39)43)49(45,46)41(2)3/h17-18,20-21,23-24,33-34H,4-16,19,22,25-32H2,1-3H3

SMILES Code: CCCCCCCCCCCCCCCC(=O)OCCC1CCN(CCCN2c3ccccc3Sc4ccc(cc24)S(=O)(=O)N(C)C)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 714.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dinesh M, David A, Quraishi SN. Depot pipotiazine palmitate and undecylenate for schizophrenia. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD001720. Review. PubMed PMID: 15495016.

2: De Schepper PJ, Vranckx C, Verbeeck R, Van den Berghe ML. Pipotiazine pharmacokinetics after p.o. and i.v. administration in man. Correlation between blood levels and effect on the handwriting area. Arzneimittelforschung. 1979;29(7):1056-62. PubMed PMID: 40577.

3: Scatton B, Boireau A, Garret C, Glowinski J, Julou L. Action of the palmitic ester of pipotiazine on dopamine metabolism in the nigro-striatal, meso-limbic and meso-cortiacal systems. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan;296(2):169-75. PubMed PMID: 13318.

4: Gallant DM, Mielke D, Bishop G, Oelsner T, Guerrero-Figueroa R. Pipotiazine palmitate: an evaluation of a new long acting intramuscular antipsychotic agent in severely ill schizophrenic patients. Dis Nerv Syst. 1975 Apr;36(4):193-6. PubMed PMID: 1090427.

5: Simpson GM, Varga V. Pipotiazine palmitate: a new depot neuroleptic. Curr Ther Res Clin Exp. 1975 Mar;17(3):276-80. PubMed PMID: 236151.

6: Smith M, de Souza MA, Pugliese S, Mari Jde J. In vivo study of the mutagenicity of biperidine, pipotiazine, chlorpromazine, and haloperidol. Am J Med Genet. 1996 Apr 9;67(2):238. PubMed PMID: 8723058.

7: Hyrman V. Pipotiazine palmitate, a long acting drug, indeed: a case report. Can J Psychiatry. 1985 Apr;30(3):221-2. PubMed PMID: 2859922.