IDX-320

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576587

CAS#: 1251165-81-7

Description: IDX-320 is an HCV protease inhibitor.

Chemical Structure

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IDX-320
CAS# 1251165-81-7
Instruction

Theoretical Analysis

MedKoo Cat#: 576587
Name: IDX-320
CAS#: 1251165-81-7
Chemical Formula: C37H43F3N6O7S2
Exact Mass: 804.26
Molecular Weight: 804.900
Elemental Analysis: C, 55.21; H, 5.39; F, 7.08; N, 10.44; O, 13.91; S, 7.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: IDX 320; IDX320; IDX-320

IUPAC/Chemical Name: (2S,13aS,14aR,16aS,Z)-2-((7-methoxy-8-methyl-2-(4-(trifluoromethyl)thiazol-2-yl)quinolin-4-yl)oxy)-7-methyl-N-((1-methylcyclopropyl)sulfonyl)-6,16-dioxo-1,3,4,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[g]pyrido[1,2-c][1,3,6]triazacyclotetradecine-14a(2H)-carboxamide

InChi Key: YEPBUHWNLNKZBW-UEMKMYPFSA-N

InChi Code: 1S/C37H43F3N6O7S2/c1-21-27(52-4)11-10-24-28(18-25(41-30(21)24)32-42-29(20-54-32)37(38,39)40)53-23-12-16-46-26(17-23)31(47)43-36(33(48)44-55(50,51)35(2)13-14-35)19-22(36)9-7-5-6-8-15-45(3)34(46)49/h7,9-11,18,20,22-23,26H,5-6,8,12-17,19H2,1-4H3,(H,43,47)(H,44,48)/b9-7-/t22-,23+,26+,36-/m1/s1

SMILES Code: COc1ccc2c(O[C@H]3CCN4[C@@H](C3)C(=O)N[C@@]5(C[C@H]5\C=C/CCCCN(C)C4=O)C(=O)NS(=O)(=O)C6(C)CC6)cc(nc2c1C)c7nc(cs7)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 804.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Parsy CC, Alexandre FR, Bidau V, Bonnaterre F, Brandt G, Caillet C, Cappelle S, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos LB, Leroy F, Liuzzi M, Loi AG, Moulat L, Chiara M, Rahali H, Roques V, Rosinovsky E, Savin S, Seifer M, Standring D, Surleraux D. Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5427-36. doi: 10.1016/j.bmcl.2015.09.009. Epub 2015 Sep 5. PMID: 26410074.

2. de Bruijne J, van Vliet A, Weegink CJ, Mazur W, Wiercinska-Drapało A, Simon K, Cholewińska-Szymańska G, Kapocsi J, Várkonyi I, Zhou XJ, Temam MF, Molles J, Chen J, Pietropaolo K, McCarville JF, Sullivan-Bólyai JZ, Mayers D, Reesink H. Rapid decline of viral RNA in chronic hepatitis C patients treated once daily with IDX320: a novel macrocyclic HCV protease inhibitor. Antivir Ther. 2012;17(4):633-42. doi: 10.3851/IMP2078. Epub 2012 Mar 16. PMID: 22427481.

3. Kishimoto M, Doi S, Shimizu J, Lee KJ, Iwasaki T, Miyake Y, Yamada K. Influence of osmolarity of contrast medium and saline flush on computed tomography angiography: comparison of monomeric and dimeric iodinated contrast media with different iodine concentrations at an identical iodine delivery rate. Eur J Radiol. 2010 Oct;76(1):135-9. doi: 10.1016/j.ejrad.2009.05.018. Epub 2009 Jun 6. PMID: 19501993.