PNX-20

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464545

CAS#: unknown

Description: PNX-20 is a novel GPR173 agonist, promoting osteoblastic differentiation of MC3T3-E1 cells. stimulating mRNAs encoding hypothalamo-pituitary-gonadal hormones.

Chemical Structure

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PNX-20
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 464545
Name: PNX-20
CAS#: unknown
Chemical Formula: C101H153N25O29
Exact Mass: 2,180.13
Molecular Weight: 2,181.481
Elemental Analysis: C, 55.61; H, 7.07; N, 16.05; O, 21.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: PNX-20; PNX20; PNX 20; Phoenixin-20; Phoenixin 20; AGIVQEDVQPPGLKVWSDPF-NH2; AGIVQEDVQPPGLKVWSDPFNH2; AGIVQEDVQPPGLKVWSDPF NH2;

IUPAC/Chemical Name: (6S,9S,12S,15S,18S,21S)-15-((1H-indol-3-yl)methyl)-21-((S)-2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-1-((S)-1-(((2S,5S,8S,11S,14S,17S,20S,26S)-26-amino-2,14-bis(3-amino-3-oxopropyl)-20-((S)-sec-butyl)-11-(2-carboxyethyl)-8-(carboxymethyl)-5,17-diisopropyl-4,7,10,13,16,19,22,25-octaoxo-3,6,9,12,15,18,21,24-octaazaheptacosanoyl)-L-prolyl)pyrrolidin-2-yl)-9-(4-aminobutyl)-18-(hydroxymethyl)-6-isobutyl-12-isopropyl-1,4,7,10,13,16,19-heptaoxo-2,5,8,11,14,17,20-heptaazatricosan-23-oic acid

InChi Key: IQRYUACIXWOSOA-PUGGNXOESA-N

InChi Code: InChI=1S/C101H153N25O29/c1-12-54(10)83(120-76(131)48-108-85(139)55(11)103)98(152)123-82(53(8)9)95(149)113-61(31-34-73(104)128)86(140)112-62(33-36-77(132)133)87(141)116-67(44-78(134)135)91(145)122-80(51(4)5)96(150)114-63(32-35-74(105)129)99(153)126-40-22-30-72(126)101(155)125-39-20-28-70(125)93(147)109-47-75(130)110-65(41-50(2)3)89(143)111-60(27-18-19-37-102)88(142)121-81(52(6)7)97(151)117-66(43-57-46-107-59-26-17-16-25-58(57)59)90(144)119-69(49-127)92(146)118-68(45-79(136)137)100(154)124-38-21-29-71(124)94(148)115-64(84(106)138)42-56-23-14-13-15-24-56/h13-17,23-26,46,50-55,60-72,80-83,107,127H,12,18-22,27-45,47-49,102-103H2,1-11H3,(H2,104,128)(H2,105,129)(H2,106,138)(H,108,139)(H,109,147)(H,110,130)(H,111,143)(H,112,140)(H,113,149)(H,114,150)(H,115,148)(H,116,141)(H,117,151)(H,118,146)(H,119,144)(H,120,131)(H,121,142)(H,122,145)(H,123,152)(H,132,133)(H,134,135)(H,136,137)/t54-,55-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,80-,81-,82-,83-/m0/s1

SMILES Code: O=C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 2,181.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mukherjee K, Unniappan S. Mouse Gastric Mucosal Endocrine Cells are Sources and Sites of Action of Phoenixin-20. Peptides. 2021 Apr 13:170551. doi: 10.1016/j.peptides.2021.170551. Epub ahead of print. PMID: 33862165.

2: Zeng X, Li Y, Ma S, Tang Y, Li H. Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome. Neurotox Res. 2020 Oct;38(3):785-792. doi: 10.1007/s12640-020-00225-w. Epub 2020 Jul 10. PMID: 32651843.

3: Rajeswari JJ, Unniappan S. Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish. Sci Rep. 2020 Apr 14;10(1):6264. doi: 10.1038/s41598-020-63226-x. PMID: 32286445; PMCID: PMC7156445.

4: Rajeswari JJ, Blanco AM, Unniappan S. Phoenixin-20 suppresses food intake, modulates glucoregulatory enzymes, and enhances glycolysis in zebrafish. Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R917-R928. doi: 10.1152/ajpregu.00019.2020. Epub 2020 Mar 25. PMID: 32208925; PMCID: PMC7272769.

5: Wang M, Chen HP, Zhai Y, Jiang DN, Liu JY, Tian CX, Wu TL, Zhu CH, Deng SP, Li GL. Phoenixin: Expression at different ovarian development stages and effects on genes ralated to reproduction in spotted scat, Scatophagus argus. Comp Biochem Physiol B Biochem Mol Biol. 2019 Feb;228:17-25. doi: 10.1016/j.cbpb.2018.10.005. Epub 2018 Nov 10. PMID: 30423433.

6: Wang M, Deng SP, Chen HP, Jiang DN, Tian CX, Yang W, Wu TL, Zhu CH, Zhang Y, Li GL. Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus. Comp Biochem Physiol B Biochem Mol Biol. 2018 Dec;226:36-44. doi: 10.1016/j.cbpb.2018.07.007. Epub 2018 Aug 13. PMID: 30114526.

7: Lyu RM, Cowan A, Zhang Y, Chen YH, Dun SL, Chang JK, Dun NJ, Luo JJ. Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity. Acta Pharmacol Sin. 2018 May;39(5):770-773. doi: 10.1038/aps.2017.195. Epub 2018 Mar 15. PMID: 29542680; PMCID: PMC5943905.

8: Yuan T, Sun Z, Zhao W, Wang T, Zhang J, Niu D. Phoenixin: A Newly Discovered Peptide with Multi-Functions. Protein Pept Lett. 2017;24(6):472-475. doi: 10.2174/0929866524666170207154417. PMID: 28176660.

9: Cowan A, Lyu RM, Chen YH, Dun SL, Chang JK, Dun NJ. Phoenixin: A candidate pruritogen in the mouse. Neuroscience. 2015 Dec 3;310:541-8. doi: 10.1016/j.neuroscience.2015.09.055. Epub 2015 Sep 28. PMID: 26415767; PMCID: PMC4633352.

10: Anzidei M, Sacconi B, Fraioli F, Saba L, Lucatelli P, Napoli A, Longo F, Vitolo D, Venuta F, Anile M, Diso D, Bezzi M, Catalano C. Development of a prediction model and risk score for procedure-related complications in patients undergoing percutaneous computed tomography-guided lung biopsy. Eur J Cardiothorac Surg. 2015 Jul;48(1):e1-6. doi: 10.1093/ejcts/ezv172. Epub 2015 May 16. PMID: 25983080.

11: Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M, Wang R. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015 Jun 1;286:39-48. doi: 10.1016/j.bbr.2015.02.011. Epub 2015 Feb 14. PMID: 25687846.