GW-311616

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576090

CAS#: 198062-54-3

Description: GW-311616 is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase (HNE).

Chemical Structure

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GW-311616
CAS# 198062-54-3
Instruction

Theoretical Analysis

MedKoo Cat#: 576090
Name: GW-311616
CAS#: 198062-54-3
Chemical Formula: C19H31N3O4S
Exact Mass: 397.20
Molecular Weight: 397.530
Elemental Analysis: C, 57.41; H, 7.86; N, 10.57; O, 16.10; S, 8.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: (+)-GW-311616; GW-311616; GW 311616; GW311616

IUPAC/Chemical Name: Pyrrolo(3,2-b)pyrrol-2(1H)-one, hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-((2E)-1-oxo-4-(1-piperidinyl)-2-butenyl)-, (3S,3aS,6aR)-

InChi Key: NDNKNUMSTIMSHQ-URZKGLGPSA-N

InChi Code: InChI=1S/C19H31N3O4S/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3/b8-7+/t15-,17+,18-/m1/s1

SMILES Code: CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)\C=C\CN3CCCCC3)N(C1=O)S(=O)(=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 397.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jiang KL, Ma PP, Yang XQ, Zhong L, Wang H, Zhu XY, Liu BZ. Neutrophil elastase and its therapeutic effect on leukemia cells. Mol Med Rep. 2015 Sep;12(3):4165-72. doi: 10.3892/mmr.2015.3946. Epub 2015 Jun 17. PubMed PMID: 26081156; PubMed Central PMCID: PMC4526057.

2: Ma PP, Zhu D, Liu BZ, Zhong L, Zhu XY, Wang H, Zhang X, Gao YM, Hu XX. [Neutrophil elastase inhibitor on proliferation and apoptosis of U937 cells]. Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):507-11. doi: 10.3760/cma.j.issn.0253-2727.2013.06.011. Chinese. PubMed PMID: 23827109.

3: Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2;17(4):534-48. doi: 10.1016/j.cmet.2013.03.005. PubMed PMID: 23562077; PubMed Central PMCID: PMC3646573.

4: Benedek B, Kopp B, Melzig MF. Achillea millefolium L. s.l. -- is the anti-inflammatory activity mediated by protease inhibition? J Ethnopharmacol. 2007 Sep 5;113(2):312-7. Epub 2007 Jul 3. PubMed PMID: 17689902.

5: Ohbayashi H. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. Review. PubMed PMID: 12084007.