CY208-243 Mandelate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413397

CAS#: 147059-48-1 (mandelate)

Description: CY208-243 is a D1 agonist. CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. CY208-243 stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. CY208,243 was superior in improving the strength of neuronal outcome sensitivity to the working memory-related choice behavior in the T-maze.

Chemical Structure

img
CY208-243 Mandelate
CAS# 147059-48-1 (mandelate)
Instruction

Theoretical Analysis

MedKoo Cat#: 413397
Name: CY208-243 Mandelate
CAS#: 147059-48-1 (mandelate)
Chemical Formula: C27H26N2O3
Exact Mass: 274.15
Molecular Weight: 426.520
Elemental Analysis: C, 76.03; H, 6.14; N, 6.57; O, 11.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 100999-26-6 (free base)   147059-48-1 (mandelate),  

Synonym: CY 208-243; CY208-243; CY-208-243; Indolophenanthridine

IUPAC/Chemical Name: Benzeneacetic acid, alpha-hydroxy-, (R)-, compd. with (6aR-trans)-4,6,6a,7,8,12b-hexahydro-7-methylindolo[4,3-ab]phenanthridine (1:1)

InChi Key: CLKKRZVLYFLOET-UZFFZFNSSA-N

InChi Code: InChI=1S/C19H18N2.C8H8O3/c1-21-11-12-5-2-3-6-14(12)19-15-7-4-8-16-18(15)13(10-20-16)9-17(19)21;9-7(8(10)11)6-4-2-1-3-5-6/h2-8,10,17,19-20H,9,11H2,1H3;1-5,7,9H,(H,10,11)/t17-,19-;7-/m11/s1

SMILES Code: O=C(O)[C@H](O)C1=CC=CC=C1.CN(CC2=C([C@@]34[H])C=CC=C2)[C@]3([H])CC5=CNC6=C5C4=CC=C6

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 426.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Yang Y, Kocher SD, Lewis MM, Mailman RB. Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms. Front Neurosci. 2022 Jun 16;16:898051. doi: 10.3389/fnins.2022.898051. PMID: 35784852; PMCID: PMC9244699.


2: Yoshioka Y, Sugino Y, Shibagaki F, Yamamuro A, Ishimaru Y, Maeda S. Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-κB p65 through the formation of dopamine quinone in microglia. Eur J Pharmacol. 2020 Jan 5;866:172826. doi: 10.1016/j.ejphar.2019.172826. Epub 2019 Nov 29. PMID: 31790652.


3: Yang Y, Lee SM, Imamura F, Gowda K, Amin S, Mailman RB. D1 dopamine receptors intrinsic activity and functional selectivity affect working memory in prefrontal cortex. Mol Psychiatry. 2021 Feb;26(2):645-655. doi: 10.1038/s41380-018-0312-1. Epub 2018 Dec 7. PMID: 30532019; PMCID: PMC9710464.


4: Peppe A, Antal A, Tagliati M, Stanzione P, Bodis-Wollner I. D1 agonist CY208-243 attenuates the pattern electroretinogram to low spatial frequency stimuli in the monkey. Neurosci Lett. 1998 Feb 27;243(1-3):5-8. doi: 10.1016/s0304-3940(98)00068-8. PMID: 9535099.


5: Isobe S. [The role of the dopaminergic system in the rat ovary]. Nihon Naibunpi Gakkai Zasshi. 1994 May 20;70(4):457-64. Japanese. doi: 10.1507/endocrine1927.70.4_457. PMID: 7958095.


6: Mori H, Arakawa S, Ohkawa T, Ohkawa R, Takada S, Morita T, Okinaga S. The involvement of dopamine in the regulation of steroidogenesis in rat ovarian cells. Horm Res. 1994;41 Suppl 1:36-40. doi: 10.1159/000183941. PMID: 7916316.


7: Dreher JK, Jackson DM. Role of D1 and D2 dopamine receptors in mediating locomotor activity elicited from the nucleus accumbens of rats. Brain Res. 1989 May 22;487(2):267-77. doi: 10.1016/0006-8993(89)90831-7. PMID: 2525062.


8: Jackson DM, Ross SB, Edwards SR. Dopamine D2 agonist-induced behavioural depression is reversed by dopamine D1 agonists. J Neural Transm. 1989;75(3):213-20. doi: 10.1007/BF01258632. PMID: 2784489.


9: Ross SB, Jackson DM, Wallis EM, Edwards SR. Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):512-8. doi: 10.1007/BF00182724. PMID: 3261844.