GSK-1034702 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576013

CAS#: 932373-86-9

Description: GSK-1034702 HCl is a potent M1 receptor allosteric agonist.

Chemical Structure

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GSK-1034702 HCl
CAS# 932373-86-9
Instruction

Theoretical Analysis

MedKoo Cat#: 576013
Name: GSK-1034702 HCl
CAS#: 932373-86-9
Chemical Formula: C18H25ClFN3O2
Exact Mass: 369.16
Molecular Weight: 369.870
Elemental Analysis: C, 58.45; H, 6.81; Cl, 9.58; F, 5.14; N, 11.36; O, 8.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GSK-1034702 hydrochloride; GSK-1034702 HCl

IUPAC/Chemical Name: 2H-Benzimidazol-2-one, 4-fluoro-1,3-dihydro-6-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl)-, hydrochloride (1:1)

InChi Key: FDACQSJDRGVKFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H24FN3O2.ClH/c1-12-10-15(19)17-16(11-12)22(18(23)20-17)14-2-6-21(7-3-14)13-4-8-24-9-5-13;/h10-11,13-14H,2-9H2,1H3,(H,20,23);1H

SMILES Code: Cl.Cc1cc(F)c2NC(=O)N(C3CCN(CC3)C4CCOCC4)c2c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 369.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kealey S, Husbands SM, Bennacef I, Gee AD, Passchier J. Palladium-mediated oxidative carbonylation reactions for the synthesis of (11) C-radiolabelled ureas. J Labelled Comp Radiopharm. 2014 Apr;57(4):202-8. doi: 10.1002/jlcr.3151. Epub 2013 Dec 11. PubMed PMID: 24327390.

2: Scarr E. Muscarinic M1 receptor agonists: can they improve cognitive performance? Int J Neuropsychopharmacol. 2013 May;16(4):717-20. doi: 10.1017/S1461145712001113. Epub 2012 Oct 16. PubMed PMID: 23067681.

3: Nathan PJ, Watson J, Lund J, Davies CH, Peters G, Dodds CM, Swirski B, Lawrence P, Bentley GD, O'Neill BV, Robertson J, Watson S, Jones GA, Maruff P, Croft RJ, Laruelle M, Bullmore ET. The potent M1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. Int J Neuropsychopharmacol. 2013 May;16(4):721-31. doi: 10.1017/S1461145712000752. Epub 2012 Aug 29. PubMed PMID: 22932339.

4: Huiban M, Pampols-Maso S, Passchier J. Fully automated synthesis of the M₁ receptor agonist [¹¹C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system. Appl Radiat Isot. 2011 Oct;69(10):1390-4. doi: 10.1016/j.apradiso.2011.05.007. Epub 2011 May 18. PubMed PMID: 21605979.