Contignasterol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413270

CAS#: 137571-30-3

Description: Contignasterol is a biochemical

Chemical Structure

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Contignasterol
CAS# 137571-30-3
Instruction

Theoretical Analysis

MedKoo Cat#: 413270
Name: Contignasterol
CAS#: 137571-30-3
Chemical Formula: C29H48O7
Exact Mass: 508.34
Molecular Weight: 508.696
Elemental Analysis: C, 68.47; H, 9.51; O, 22.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Contignasterol; IZP94005; IZP 94005; IZP-94005

IUPAC/Chemical Name: Stigmas-tan-15-one, 22,29-epoxy-3,4,6,7,29-pentahydroxy-, (3-alpha,4-beta,5-alpha,6-alpha,7-beta,14-beta,22S)-

InChi Key: IRHVLQMEQPABHG-ZLYSWTFPSA-N

InChi Code: InChI=1S/C29H48O7/c1-13(2)15-10-20(36-21(32)11-15)14(3)17-12-19(31)23-22-16(6-8-29(17,23)5)28(4)9-7-18(30)25(33)24(28)27(35)26(22)34/h13-18,20-27,30,32-35H,6-12H2,1-5H3/t14-,15-,16-,17+,18+,20-,21?,22+,23+,24+,25-,26+,27+,28+,29+/m0/s1

SMILES Code: CC(C)[C@H](CC(O)O1)C[C@H]1[C@@H](C)[C@H]2CC([C@]3([H])[C@]4([H])[C@@H](O)[C@H](O)[C@@]5([H])[C@@H](O)[C@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 508.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Coulson FR, O'Donnell SR. The effects of contignasterol (IZP-94,005) on allergen-induced plasma protein exudation in the tracheobronchial airways of sensitized guinea-pigs in vivo. Inflamm Res. 2000 Mar;49(3):123-7. doi: 10.1007/s000110050569. PMID: 10807500.

2: Takei M, Burgoyne DL, Andersen RJ. Effect of contignasterol on histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells. J Pharm Sci. 1994 Sep;83(9):1234-5. doi: 10.1002/jps.2600830909. PMID: 7530301.

3: Bramley AM, Langlands JM, Jones AK, Burgoyne DL, Li Y, Andersen RJ, Salari H. Effects of IZP-94005 (contignasterol) on antigen-induced bronchial responsiveness in ovalbumin-sensitized guinea-pigs. Br J Pharmacol. 1995 Aug;115(8):1433-8. doi: 10.1111/j.1476-5381.1995.tb16634.x. PMID: 8564202; PMCID: PMC1908893.

4: Yang L, Andersen RJ. Absolute configuration of the antiinflammatory [correction of antiinflamatory] sponge natural product contignasterol. J Nat Prod. 2002 Dec;65(12):1924-6. doi: 10.1021/np020297+. PMID: 12502341.

5: Sperry S, Crews P. Haliclostanone sulfate and halistanol sulfate from an Indo-Pacific Haliclona sponge. J Nat Prod. 1997 Jan;60(1):29-32. doi: 10.1021/np960592s. PMID: 9014348.