Coleneuramide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413232

CAS#: 204200-47-5

Description: Coleneuramide is a neuroprotective agent used in treatment of Diabetic Neuropathy

Chemical Structure

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Coleneuramide
CAS# 204200-47-5
Instruction

Theoretical Analysis

MedKoo Cat#: 413232
Name: Coleneuramide
CAS#: 204200-47-5
Chemical Formula: C39H68N2O8
Exact Mass: 692.50
Molecular Weight: 692.980
Elemental Analysis: C, 67.60; H, 9.89; N, 4.04; O, 18.47

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Coleneuramide; MCC257; MCC 257; MCC-257

IUPAC/Chemical Name: (2R,4S,5R,6R)-5-acetamido-N-((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-4-hydroxy-2-methoxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxamide

InChi Key: CHMRTBYTCBDIRG-JQZMMWJVSA-N

InChi Code: InChI=1S/C39H68N2O8/c1-22(2)9-8-10-23(3)28-13-14-29-27-12-11-25-19-26(15-17-37(25,5)30(27)16-18-38(28,29)6)41-36(47)39(48-7)20-31(44)33(40-24(4)43)35(49-39)34(46)32(45)21-42/h22-23,25-35,42,44-46H,8-21H2,1-7H3,(H,40,43)(H,41,47)/t23-,25+,26-,27+,28-,29+,30+,31+,32-,33-,34-,35-,37+,38-,39-/m1/s1

SMILES Code: CO[C@]1(C(N[C@@H]2CC[C@]3([C@H](C2)CC[C@H]4[C@@H]5CC[C@@H]([C@]5(CC[C@H]34)C)[C@@H](CCCC(C)C)C)C)=O)C[C@@H]([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O1)NC(C)=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 692.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yamada MK, Konishi Y, Kakinoki B, Ikegami K, Setou M. Enhancement of Trk signaling pathways by the cholestane amide conjugate MCC-257. J Pharmacol Sci. 2008 Sep;108(1):131-4. doi: 10.1254/jphs.08109sc. Epub 2008 Aug 30. PMID: 18758136.

2: Kakinoki B, Sekimoto S, Yuki S, Ohgami T, Sejima M, Yamagami K, Saito K. Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals. Diabetes. 2006 Mar;55(3):616-21. doi: 10.2337/diabetes.55.03.06.db05-1091. PMID: 16505223.

3: Fujimura M, Usuki F. Methylmercury causes neuronal cell death through the suppression of the TrkA pathway: in vitro and in vivo effects of TrkA pathway activators. Toxicol Appl Pharmacol. 2015 Feb 1;282(3):259-66. doi: 10.1016/j.taap.2014.12.008. Epub 2014 Dec 26. PMID: 25545984.