GT-1061 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413212

CAS#: 1173928-02-3

Description: GT-1061 HCl is a novel nitrate ester in clinical trials for Alzheimer's disease, enhances cognitive performance in rats with forebrain cholinergic depletion

Chemical Structure

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GT-1061 HCl
CAS# 1173928-02-3
Instruction

Theoretical Analysis

MedKoo Cat#: 413212
Name: GT-1061 HCl
CAS#: 1173928-02-3
Chemical Formula: C6H9ClN2O3S
Exact Mass: 224.00
Molecular Weight: 224.660
Elemental Analysis: C, 32.08; H, 4.04; Cl, 15.78; N, 12.47; O, 21.36; S, 14.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GT-1061; GT1061; GT 1061; GT-1061 HCl; GT-1061 hydrochloride

IUPAC/Chemical Name: 2-(4-Methylthiazol-5-yl)ethyl nitrate hydrochloride

InChi Key: AFJHNVYIRRYUJM-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H8N2O3S.ClH/c1-5-6(12-4-7-5)2-3-11-8(9)10;/h4H,2-3H2,1H3;1H

SMILES Code: O=[N+]([O-])OCCC1=C(C)N=CS1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 224.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Beninger RJ, Forsyth JK, Van Adel M, Reynolds JN, Boegman RJ, Jhamandas K. Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061. Pharmacol Biochem Behav. 2009 Feb;91(4):495-502. doi: 10.1016/j.pbb.2008.09.003. Epub 2008 Sep 10. PMID: 18834899.

2: Thatcher GR, Bennett BM, Reynolds JN. NO chimeras as therapeutic agents in Alzheimer's disease. Curr Alzheimer Res. 2006 Jul;3(3):237-45. doi: 10.2174/156720506777632925. PMID: 16842101.

3: Thatcher GR, Bennett BM, Dringenberg HC, Reynolds JN. Novel nitrates as NO mimetics directed at Alzheimer's disease. J Alzheimers Dis. 2004 Dec;6(6 Suppl):S75-84. doi: 10.3233/jad-2004-6s614. PMID: 15665418.

4: Thatcher GR, Bennett BM, Reynolds JN. Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease. Curr Alzheimer Res. 2005 Apr;2(2):171-82. doi: 10.2174/1567205053585945. PMID: 15974915.

5: Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. ACS Med Chem Lett. 2011 Sep 8;2(9):656-661. doi: 10.1021/ml2000033. PMID: 21927645; PMCID: PMC3171965.

6: Bennett BM, Reynolds JN, Prusky GT, Douglas RM, Sutherland RJ, Thatcher GR. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Neuropsychopharmacology. 2007 Mar;32(3):505-13. doi: 10.1038/sj.npp.1301054. Epub 2006 Mar 8. PMID: 16525416.