Acetylstrophanthidin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463958

CAS#: 60-38-8

Description: Acetylstrophanthidin is an acetate ester that is strophanidin acetylated at the 3beta-hydroxy group. It has a role as an anti-arrhythmia drug. It derives from a strophanthidin.

Chemical Structure

img
Acetylstrophanthidin
CAS# 60-38-8
Instruction

Theoretical Analysis

MedKoo Cat#: 463958
Name: Acetylstrophanthidin
CAS#: 60-38-8
Chemical Formula: C25H34O7
Exact Mass: 446.23
Molecular Weight: 446.540
Elemental Analysis: C, 67.24; H, 7.68; O, 25.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Acetylstrophanthidin; Acetylstrophanthidine; Strophanthidin acetate; NSC 92954; NSC-92954; NSC92954;

IUPAC/Chemical Name: (3S,5S,8R,9S,10S,13R,14S,17R)-10-formyl-5,14-dihydroxy-13-methyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

InChi Key: JLZAERUVCODZQO-VWCUIIQSSA-N

InChi Code: InChI=1S/C25H34O7/c1-15(27)32-17-3-8-23(14-26)19-4-7-22(2)18(16-11-21(28)31-13-16)6-10-25(22,30)20(19)5-9-24(23,29)12-17/h11,14,17-20,29-30H,3-10,12-13H2,1-2H3/t17-,18+,19-,20+,22+,23-,24-,25-/m0/s1

SMILES Code: CC(O[C@H]1CC[C@@]2([C@H]3CC[C@@]4([C@@H](C5=CC(OC5)=O)CC[C@@]4([C@@H]3CC[C@@]2(C1)O)O)C)C=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 446.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Altamirano J, Li Y, DeSantiago J, Piacentino V 3rd, Houser SR, Bers DM. The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function. J Physiol. 2006 Sep 15;575(Pt 3):845-54. doi: 10.1113/jphysiol.2006.111252. Epub 2006 Jul 6. PMID: 16825310; PMCID: PMC1995692.

2: Wallick DW, Dunlap ME, Stuesse SS, Thames MD. Denervation of vagal cardiopulmonary receptors by injection of kainic acid into the nodose ganglia in dogs. Auton Neurosci. 2002 Nov 29;102(1-2):85-9. doi: 10.1016/s1566-0702(02)00176-5. PMID: 12492140.

3: Veloso HH. Effects of cardiac glycosides on atrial fibrillation. Chest. 2001 Nov;120(5):1753-4. doi: 10.1378/chest.120.5.1753. PMID: 11713174.

4: Xie JT, Dey L, Yuan CS. Biphasic effect of cardiac glycosides on action potential duration in isolated Purkinje fibers. Pharmacol Toxicol. 2001 Sep;89(3):145-8. doi: 10.1034/j.1600-0773.2001.d01-149.x. PMID: 11589786.

5: Fisher KV, Telser A, Phillips JE, Yeates DB. Regulation of vocal fold transepithelial water fluxes. J Appl Physiol (1985). 2001 Sep;91(3):1401-11. doi: 10.1152/jappl.2001.91.3.1401. PMID: 11509542.

6: Xie JT, Lowell TK, Yuan CS. Extracellular detection of delayed afterdepolarization of cardiac fibers using signal averaging technique. Acta Pharmacol Sin. 2000 Nov;21(11):977-85. PMID: 11501065.

7: Chen BT, Yeates DB. Ion transport and regulation of respiratory tract fluid output in dogs. J Appl Physiol (1985). 2001 Mar;90(3):821-31. doi: 10.1152/jappl.2001.90.3.821. PMID: 11181589.

8: Friedman HS, Win M, Hussain A, Sinha A. Effects of cardiac glycosides on atrial contractile dysfunction after short-term atrial fibrillation. Chest. 2000 Oct;118(4):1116-26. doi: 10.1378/chest.118.4.1116. PMID: 11035687.

9: Xie JT, Yuan CS, Zhou Z, January CT. Enhancement of delayed afterdepolarizations and triggered activity by class III antiarrhythmic drugs: multiple effects of E-4031 and dofetilide. Methods Find Exp Clin Pharmacol. 2000 Mar;22(2):67-76. doi: 10.1358/mf.2000.22.2.796064. PMID: 10849888.

10: Xie JT, Chen W, Cunningham PM, January CT. Effect of acetylstrophanthidin on action potential duration and relation with extracellular potassium in sheep isolated Purkinje fibers. Zhongguo Yao Li Xue Bao. 1998 Jul;19(4):309-12. PMID: 10375773.

11: Phillips JE, Wong LB, Yeates DB. Bidirectional transepithelial water transport: measurement and governing mechanisms. Biophys J. 1999 Feb;76(2):869-77. doi: 10.1016/S0006-3495(99)77250-4. PMID: 9929488; PMCID: PMC1300088.

12: Teter K, Chandy G, Quiñones B, Pereyra K, Machen T, Moore HP. Cellubrevin- targeted fluorescence uncovers heterogeneity in the recycling endosomes. J Biol Chem. 1998 Jul 31;273(31):19625-33. doi: 10.1074/jbc.273.31.19625. PMID: 9677389.

13: Winters SL, Yeates DB. Interaction between ion transporters and the mucociliary transport system in dog and baboon. J Appl Physiol (1985). 1997 Oct;83(4):1348-59. doi: 10.1152/jappl.1997.83.4.1348. PMID: 9338446.

14: Gutstein DE, Flemmal K, Bruce E, Travers KE, Gwathmey JK, Ransil BJ, Markis JE, Grossman W, Morgan JP. Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium. J Card Fail. 1996 Dec;2(4):285-92. doi: 10.1016/s1071-9164(96)80015-7. PMID: 8989643.

15: Self CH, Dessi JL, Winger LA. Ultra-specific immunoassays for small molecules: roles of wash steps and multiple binding formats. Clin Chem. 1996 Sep;42(9):1527-31. PMID: 8787724.

16: Escobar MR, Sitar DS. Use of digitalis glycosides to identify the mechanisms of amantadine transport by renal tubules. J Pharmacol Exp Ther. 1996 Jun;277(3):1189-94. PMID: 8667177.

17: Szigligeti P, Pankucsi C, Bányász T, Varró A, Nánási PP. Action potential duration and force-frequency relationship in isolated rabbit, guinea pig and rat cardiac muscle. J Comp Physiol B. 1996;166(2):150-5. doi: 10.1007/BF00301179. PMID: 8766913.

18: Poulter MO, Hashiguchi T, Padjen AL. Evidence for a sodium-dependent potassium conductance in frog myelinated axon. Neuroscience. 1995 Sep;68(2):487-95. doi: 10.1016/0306-4522(95)00138-9. PMID: 7477959.

19: Shi WB, Xu YQ. [Excitatory effect of alpha-adrenoceptor on the transient inward current in sheep myocardium]. Sheng Li Xue Bao. 1995 Aug;47(4):387-93. Chinese. PMID: 7481881.

20: Shi WB, Xu YQ, Chen XL, Yu PD. Influences of phenylephrine on delayed afterdepolarization and triggered activity in sheep Purkinje fibers. Zhongguo Yao Li Xue Bao. 1995 May;16(3):243-6. PMID: 7660820.