Chlorquinaldol | CAS# 72-80-0 | anti-infective

Chlorquinaldol
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413157

CAS#: 72-80-0

Description: Chlorquinaldol is a local anti-infective agent used for skin, gastrointestinal, and vaginal infections with fungi, protozoa, and certain bacteria. In animals, it causes central nervous system damage and is not administered parenterally. It is also used as antiseptic, fungistat, or deodorant.

Chemical Structure

Chlorquinaldol

CAS# 72-80-0

Instruction

Theoretical Analysis

MedKoo Cat#: 413157
Name: Chlorquinaldol
CAS#: 72-80-0
Chemical Formula: C10H7Cl2NO
Exact Mass: 226.99
Molecular Weight: 228.070
Elemental Analysis: C, 52.66; H, 3.09; Cl, 31.09; N, 6.14; O, 7.01

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
10g	USD 400	2 Weeks
25g	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Chlorquinaldol; BRN0156683; BRN-0156683; BRN 0156683

IUPAC/Chemical Name: 5,7-Dichloro-2-methyl-8-quinolinol

InChi Key: GPTXWRGISTZRIO-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3

SMILES Code: OC1=C2N=C(C)C=CC2=C(Cl)C=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 228.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bidossi A, Bottagisio M, De Grandi R, Drago L, De Vecchi E. Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm- related antimicrobial cross-resistance. Infect Drug Resist. 2019 Jul 19;12:2177-2189. doi: 10.2147/IDR.S211007. PMID: 31410037; PMCID: PMC6650094.

2: Veraldi S, Schianchi R, Esposito L, Pontini P, Nazzaro G. Treatment of postscabies prurigo with diflucortolone and chlorquinaldol in a group of African refugees. Trop Doct. 2019 Oct;49(4):268-270. doi: 10.1177/0049475519855577. Epub 2019 Jun 18. PMID: 31208292.

3: Wang L, Deng K, Gong L, Zhou L, Sayed S, Li H, Sun Q, Su Z, Wang Z, Liu S, Zhu H, Song J, Lu D. Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity. Pharmacol Res. 2020 Sep;159:104955. doi: 10.1016/j.phrs.2020.104955. Epub 2020 May 30. PMID: 32485279.

4: Chen X, Guo H. Comparison of Chlorquinaldol-Promestriene Vaginal Tablets and Opin Suppositories Effect on Inflammatory Factors and Immune Function in Chronic HPV Cervicitis. J Coll Physicians Surg Pak. 2019 Feb;29(2):115-118. doi: 10.29271/jcpsp.2019.02.115. PMID: 30700347.

5: Bortolin M, Bidossi A, De Vecchi E, Avveniente M, Drago L. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017 Jun 8;8:1039. doi: 10.3389/fmicb.2017.01039. PMID: 28642751; PMCID: PMC5462991.

6: Agner T, Menné T. Sensitivity to clioquinol and chlorquinaldol in the quinoline mix. Contact Dermatitis. 1993 Sep;29(3):163. doi: 10.1111/j.1600-0536.1993.tb03524.x. PMID: 8222638.

7: Myatt AE, Beck MH. Contact sensitivity to chlorquinaldol. Contact Dermatitis. 1983 Nov;9(6):523. doi: 10.1111/j.1600-0536.1983.tb04485.x. PMID: 6228382.

8: Degen PH, Moppert J, Schmid K, Weirich EG. Percutaneous absorption of chlorquinaldol (Sterosan). Dermatologica. 1979;159(3):239-44. doi: 10.1159/000250600. PMID: 478062.

9: Corrihons I, Dutilh B, Bébéar C. Activité in vitro d'un antiseptique, le chlorquinaldol, sur Neisseria gonorrhoeae et Chlamydia trachomatis [In vitro activity of an antiseptic, chlorquinaldol, against Neisseria gonorrhoeae and Chlamydia trachomatis]. Pathol Biol (Paris). 1991 Feb;39(2):136-9. French. PMID: 1901985.

10: Rosanove R. Chlorquinaldol ("Steroxin") with hydrocortisone in the therapy of common dermatoses. Med J Aust. 1966 Jan 8;1(2):54-5. PMID: 5902021.

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