Clofluperol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413113

CAS#: 10457-91-7

Description: Clofluperol is a biochemical

Chemical Structure

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Clofluperol
CAS# 10457-91-7
Instruction

Theoretical Analysis

MedKoo Cat#: 413113
Name: Clofluperol
CAS#: 10457-91-7
Chemical Formula: C22H22ClF4NO2
Exact Mass: 443.13
Molecular Weight: 443.867
Elemental Analysis: C, 59.53; H, 5.00; Cl, 7.99; F, 17.12; N, 3.16; O, 7.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Clofluperol; Seperidol; Clofluperolum

IUPAC/Chemical Name: 4-(4-(4-Chloro-3-(trifluoromethyl)phenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone

InChi Key: LZFSKNPPWIFMFL-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H22ClF4NO2/c23-19-8-5-16(14-18(19)22(25,26)27)21(30)9-12-28(13-10-21)11-1-2-20(29)15-3-6-17(24)7-4-15/h3-8,14,30H,1-2,9-13H2

SMILES Code: O=C(C1=CC=C(F)C=C1)CCCN2CCC(O)(C3=CC=C(Cl)C(C(F)(F)F)=C3)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 443.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chiou GC. Treatment of ocular hypertension and glaucoma with dopamine antagonists. Ophthalmic Res. 1984;16(3):129-34. doi: 10.1159/000265307. PMID: 6147806.

2: Aimoto T, Masuda C, Murata T. [Biopharmaceutical studies on neuroleptic butyrophenones. IV. Sex differences in the disposition of clofluperol in the rat (author's transl)]. Yakugaku Zasshi. 1979 Aug;99(8):851-4. Japanese. doi: 10.1248/yakushi1947.99.8_851. PMID: 541776.

3: Janssen PA, Allewijn FT. The distribution of the butyrophenones haloperidol, trifluperidol, moperone, and clofluperol in rats, and its relationship with their neuroleptic activity. Arzneimittelforschung. 1969 Feb;19(2):199-208. PMID: 5818759.

4: Bobon J, Pinchard A, Goffioul F, Devroye A, Bobon DP, Korn M. Neuroleptiques à longue durée d'action. I. Etude pilote du clofluperol (R9298) [Long-acting neuroleptics. I. Pilot study of clofluperol (R9298)]. Acta Neurol Psychiatr Belg. 1968 Feb;68(2):128-36. French. PMID: 4972601.

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6: Aimoto T, Kaida M, Sato M, Sato M, Kimura R, Murata T. Effects of neuroleptic butyrophenones on pituitary-adrenal activity in rats. J Pharmacobiodyn. 1980 Jan;3(1):46-52. doi: 10.1248/bpb1978.3.46. PMID: 6110713.

7: Aimoto T, Kaida M, Numazaki K, Masuda Y, Murata T. Development of tolerance to the stimulatory effect of neuroleptic butyrophenones on pituitary-adrenal activity in rats. J Pharmacobiodyn. 1981 Nov;4(11):827-32. doi: 10.1248/bpb1978.4.827. PMID: 6120222.

8: Aimoto T, Unno K, Hayashi H, Murata T. [Biopharmaceutical studies on neuroleptic butyrophenones. V. Effects of chronic treatment on adrenal and hepatic drug-metabolizing enzyme system in rats (author's transl)]. Yakugaku Zasshi. 1979 Oct;99(10):1014-20. Japanese. doi: 10.1248/yakushi1947.99.10_1014. PMID: 544743.