Chrysarobin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412851

CAS#: 491-59-8

Description: Chrysarobin is an extract of Goa powder; a complex mixture of reduction products of chrysophanic acid, emodin, and emodin monomethyl ether; used locally in ringworm, psoriasis, and eczema. from NCIt. Chrysophanol-9-anthrone is a member of anthracenes. It derives from an anthralin.

Chemical Structure

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Chrysarobin
CAS# 491-59-8
Instruction

Theoretical Analysis

MedKoo Cat#: 412851
Name: Chrysarobin
CAS#: 491-59-8
Chemical Formula: C15H12O3
Exact Mass: 240.08
Molecular Weight: 240.260
Elemental Analysis: C, 74.99; H, 5.03; O, 19.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Chrysarobin; CCRIS5597; CCRIS-5597; CCRIS 5597

IUPAC/Chemical Name: 3-methylanthracene-1,8,9-triol

InChi Key: JBGKVNQFVAJOGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H12O3/c1-8-5-10-7-9-3-2-4-11(16)13(9)15(18)14(10)12(17)6-8/h2-7,16-18H,1H3

SMILES Code: Cc(cc1O)cc2c1c(O)c(c(O)ccc3)c3c2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 240.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: BOYMOND P, JADASSOHN W. A propos de la chrysarobine [About chrysarobin]. Dermatologica. 1947;94(4):228-30. French. PMID: 18898893.

2: Kruszewski FH, DiGiovanni J. Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice. Cancer Res. 1988 Nov 15;48(22):6390-5. PMID: 3180057.

3: Kruszewski FH, Conti CJ, DiGiovanni J. Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice. Cancer Res. 1987 Jul 15;47(14):3783-90. PMID: 3109733.

4: DiGiovanni J, Decina PC, Prichett WP, Cantor J, Aalfs KK, Coombs MM. Mechanism of mouse skin tumor promotion by chrysarobin. Cancer Res. 1985 Jun;45(6):2584-9. PMID: 3986797.

5: Battalora MS, Conti CJ, Aldaz CM, Slaga TJ, Johnston DA, DiGiovanni J. Regression and progression characteristics of papillomas induced by chrysarobin in SENCAR mice. Carcinogenesis. 1996 May;17(5):955-60. doi: 10.1093/carcin/17.5.955. PMID: 8640943.

6: Battalora MS, Kruszewski FH, DiGiovanni J. Inhibition of chrysarobin skin tumor promotion in SENCAR mice by antioxidants. Carcinogenesis. 1993 Dec;14(12):2507-12. doi: 10.1093/carcin/14.12.2507. PMID: 8269619.

7: DiGiovanni J, Kruszewski FH, Chenicek KJ. Modulation of chrysarobin skin tumor promotion. Carcinogenesis. 1988 Aug;9(8):1445-50. doi: 10.1093/carcin/9.8.1445. PMID: 3135955.

8: NANASI P, KOCSIS A. Beitrag zum Wirkungsmechanismus des Chrysarobins [Pharmacology of chrysarobin]. Dermatol Wochenschr. 1951;124(41):1001-3. Undetermined Language. PMID: 14905945.

9: O'Brien TG, O'Donnell K, Kruszewski FH, DiGiovanni J. Presence of a functionally altered ornithine decarboxylase activity in chrysarobin-promoted mouse epidermal papillomas. Carcinogenesis. 1988 Nov;9(11):2081-5. doi: 10.1093/carcin/9.11.2081. PMID: 3141077.

10: Sehgal VN, Verma P, Khurana A. Anthralin/dithranol in dermatology. Int J Dermatol. 2014 Oct;53(10):e449-60. doi: 10.1111/j.1365-4632.2012.05611.x. Epub 2014 Sep 10. PMID: 25208745.