Quindonium bromide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412823

CAS#: 130-81-4

Description: Quindonium bromide is a Cardiac Depressant (Anti-Arrhythmic)

Chemical Structure

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Quindonium bromide
CAS# 130-81-4
Instruction

Theoretical Analysis

MedKoo Cat#: 412823
Name: Quindonium bromide
CAS#: 130-81-4
Chemical Formula: C16H20BrNO
Exact Mass: 321.07
Molecular Weight: 322.250
Elemental Analysis: C, 59.64; H, 6.26; Br, 24.80; N, 4.35; O, 4.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Quindonium bromide; W3366A; W-3366A; W 3366A

IUPAC/Chemical Name: 1H-Benzo(a)cyclopenta(f)quinolizinium, 2,3,3a,5,6,11,12,12a-octahydro-8-hydroxy-, bromide

InChi Key: OUILVKYDBNPYBM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19NO.BrH/c18-13-5-6-14-12(10-13)8-9-17-15-3-1-2-11(15)4-7-16(14)17;/h5-6,10-11,15H,1-4,7-9H2;1H

SMILES Code: OC1=CC=C2C(CC[N+]3=C2CCC4C3CCC4)=C1.[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 322.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: OSBORNE MW, WINBURY MM. QUINDONIUM BROMIDE--SOME ASPECTS OF THE CARDIOVASCULAR PHARMACOLOGY. J Pharmacol Exp Ther. 1965 Feb;147:212-24. PMID: 14259499.

2: Kaplan HR, La Sala SA. Quindonium bromide: cardiac rate and rhythm disturbances in barbiturate. Anesthetized dogs. J Pharmacol Exp Ther. 1972 Apr;181(1):98-107. PMID: 5013159.

3: Gupta RS, Chopra A, Stetsko DK. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol. 1986 May;127(2):197-206. doi: 10.1002/jcp.1041270202. PMID: 3009493.

4: Lum BK, Allen DO. Protection against traumatic shock by pretreatment with quindonium bromide. Arch Int Pharmacodyn Ther. 1967 Sep;169(1):185-8. PMID: 6055127.

5: Gupta RS, Chopra A. Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453. J Biol Chem. 1985 Jun 10;260(11):6843-50. PMID: 2987235.

6: OSBORNE MW, ROWE HM, KAUFMAN RN, JOHNSON MC, WILLEMS W, WINBURY MM. PROTECTIVE ACTION OF QUINDONIUM BROMIDE (W3366A) AGAINST HEMORRHAGE SHOCK IN DOGS. J Pharmacol Exp Ther. 1965 Feb;147:225-31. PMID: 14259500.