Chaetoviridin B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412792

CAS#: 128230-03-5

Description: Chaetoviridin B is an organic heterotetracyclic compound that exhibits antifungal activity against plant pathogenic fungi.

Chemical Structure

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Chaetoviridin B
CAS# 128230-03-5
Instruction

Theoretical Analysis

MedKoo Cat#: 412792
Name: Chaetoviridin B
CAS#: 128230-03-5
Chemical Formula: C23H29ClO7
Exact Mass: 452.16
Molecular Weight: 452.930
Elemental Analysis: C, 60.99; H, 6.45; Cl, 7.83; O, 24.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Chaetoviridin B; ChaetoviridinB; Chaetoviridin-B

IUPAC/Chemical Name: 6H-Furo(2,3-h)-2-benzopyran-9-carboxylic acid, 5-chloro-6a,8,9,9a-tetrahydro-8-hydroxy-8-(2-hydroxy-1-methylpropyl)-6a-methyl-3-(3-methyl-1-pentenyl)-6-oxo

InChi Key: TVZGDEYWRLMKPX-BQYQJAHWSA-N

InChi Code: InChI=1S/C23H29ClO7/c1-6-11(2)7-8-14-9-15-16(10-30-14)17-18(21(27)28)23(29,12(3)13(4)25)31-22(17,5)20(26)19(15)24/h7-13,17-18,25,29H,6H2,1-5H3,(H,27,28)/b8-7+

SMILES Code: O=C(C1C(C(C)C(O)C)(O)OC2(C)C1C3=COC(/C=C/C(C)CC)=CC3=C(Cl)C2=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 452.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yue HM, Wang M, Gong WF, Zhang LQ. The screening and identification of the biological control fungi Chaetomium spp. against wheat common root rot. FEMS Microbiol Lett. 2018 Nov 1;365(22). doi: 10.1093/femsle/fny242. PMID: 30289449.

2: Chen GD, Li YJ, Gao H, Chen Y, Li XX, Li J, Guo LD, Cen YZ, Yao XS. New azaphilones and chlorinated phenolic glycosides from Chaetomium elatum with caspase-3 inhibitory activity. Planta Med. 2012 Oct;78(15):1683-9. doi: 10.1055/s-0032-1315211. Epub 2012 Aug 13. PMID: 22890540.

3: Tomoda H, Matsushima C, Tabata N, Namatame I, Tanaka H, Bamberger MJ, Arai H, Fukazawa M, Inoue K, Omura S. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. J Antibiot (Tokyo). 1999 Feb;52(2):160-70. doi: 10.7164/antibiotics.52.160. PMID: 10344570.

4: Awad NE, Kassem HA, Hamed MA, El-Naggar MA, El-Feky AM. Bioassays guided isolation of compounds from Chaetomium globosum. J Mycol Med. 2014 Jun;24(2):e35-42. doi: 10.1016/j.mycmed.2013.10.005. Epub 2013 Dec 19. PMID: 24361402.

5: Park JH, Choi GJ, Jang KS, Lim HK, Kim HT, Cho KY, Kim JC. Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosum. FEMS Microbiol Lett. 2005 Nov 15;252(2):309-13. doi: 10.1016/j.femsle.2005.09.013. Epub 2005 Sep 21. PMID: 16209910.

6: Youn UJ, Sripisut T, Park EJ, Kondratyuk TP, Fatima N, Simmons CJ, Wall MM, Sun D, Pezzuto JM, Chang LC. Determination of the absolute configuration of chaetoviridins and other bioactive azaphilones from the endophytic fungus Chaetomium globosum. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4719-4723. doi: 10.1016/j.bmcl.2015.08.063. Epub 2015 Aug 24. PMID: 26343828.