Chinoin 127

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412779

CAS#: 54606-29-0

Description: Chinoin 127 is a biochemical

Chemical Structure

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Chinoin 127
CAS# 54606-29-0
Instruction

Theoretical Analysis

MedKoo Cat#: 412779
Name: Chinoin 127
CAS#: 54606-29-0
Chemical Formula: C11H17N3O2
Exact Mass: 223.13
Molecular Weight: 223.280
Elemental Analysis: C, 59.17; H, 7.67; N, 18.82; O, 14.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Chinoin 127; CH127; CH-127; CH 127

IUPAC/Chemical Name: 4H-Pyrido(1,2-a)pyrimidine-3-carboxamide, 1,6,7,8,9,9a-hexahydro-1,6-dimethyl-4-oxo-

InChi Key: PDYZVPFJLHCRGG-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H17N3O2/c1-7-4-3-5-9-13(2)6-8(10(12)15)11(16)14(7)9/h6-7,9H,3-5H2,1-2H3,(H2,12,15)

SMILES Code: O=C(C1=CN(C)C(CCCC2C)N2C1=O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 223.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kalmár L, Láng I, Gonzelez-Cabello P, Gergely P, Fehér J. Effects on immune reactions of non-steroidal anti-inflammatory drugs and of two new pyrido- pyrimidine derivatives (CHINOIN 127 and CHINOIN 105). Acta Med Hung. 1986;43(3):255-63. PMID: 3295745.

2: Bernus I, Tóth A, Kálóy K, Takácsy TE. Analytical studies on the hydrolysis of Chinoin-102 and Chinoin-127, candidate compounds for stability studies. J Pharm Biomed Anal. 1985;3(5):405-15. doi: 10.1016/0731-7085(85)80054-6. PMID: 16867652.

3: Kapui Z, Boér K, Hermecz I, Gyíres K. The mechanism of cytoprotective effect of CHINOIN-127. Acta Physiol Hung. 1992;80(1-4):237-45. PMID: 1345193.

4: Gergelyné-Zobin A, Szász G, Hermecz I. Pirido-pirimidin-karboxamid (CHINOIN-127) dehidrogénezödéssel járó bomlásáról [Dehydrogenation accompanied decomposition of pyrido-pyrimidine carboxamide (CHINOIN-127)]. Acta Pharm Hung. 1983 Sep;53(5):222-8. Hungarian. PMID: 6605660.

5: Kovács Z, Kapui Z, Cser I, Hermecz I, Rózsa I, Blaskó G. The gastroprotective effect of CHINOIN-127 on indomethacin induced gastric ulcer in rats. Acta Physiol Hung. 1990;75 Suppl:185-6. PMID: 2115229.

6: Knoll J, Gyires K, Mészáros Z. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido [1,2-a] pyrimidine-3-carboxamide (Chinoin-127), a potent non-narcotic analgesic and antiinflammatory agent. Arzneimittelforschung. 1979;29(5):766-73. PMID: 315232.

7: Knoll J, Gyires K, Hermecz I. 1,6-Dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido(1,2-a)- pyrimidine-3-carboxamide (Ch-127) protects against the intestinal damage in rats caused by two weeks' daily administration of indomethacin. Drugs Exp Clin Res. 1987;13(5):253-8. PMID: 3500028.

8: Rózsa I, Kapui Z, Szécsi T, Hermecz I, Blaskó G. Synthesis of prostacyclin and thromboxane A2 by rat gastric mucosa. Comparison of 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido (1,1-a)-pyrimidine-3-carboxamide and cimetidine. Arzneimittelforschung. 1989 Jun;39(6):686-9. PMID: 2673252.