Cgs 26393

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412775

CAS#: 154116-34-4

Description: Cgs 26393 is a prodrug of CGS-26303.

Chemical Structure

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Cgs 26393
CAS# 154116-34-4
Instruction

Theoretical Analysis

MedKoo Cat#: 412775
Name: Cgs 26393
CAS#: 154116-34-4
Chemical Formula: C28H26N5O3P
Exact Mass: 511.18
Molecular Weight: 511.520
Elemental Analysis: C, 65.75; H, 5.12; N, 13.69; O, 9.38; P, 6.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Cgs 26393; Cgs26393; Cgs-26393

IUPAC/Chemical Name: Phosphonic acid, (((2-(1,1'-biphenyl)-4-yl-1-(1H-tetrazol-5-yl)ethyl)amino)methyl)-, diphenyl ester, (S)-

InChi Key: AHIFMZUYRNPRJK-MHZLTWQESA-N

InChi Code: InChI=1S/C28H26N5O3P/c34-37(35-25-12-6-2-7-13-25,36-26-14-8-3-9-15-26)21-29-27(28-30-32-33-31-28)20-22-16-18-24(19-17-22)23-10-4-1-5-11-23/h1-19,27,29H,20-21H2,(H,30,31,32,33)/t27-/m0/s1

SMILES Code: O=P(CN[C@H](C1=NN=NN1)CC2=CC=C(C3=CC=CC=C3)C=C2)(OC4=CC=CC=C4)OC5=CC=CC=C5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 511.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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5: Pelletier S, Battistini B, Jeng AY, Sirois P. Effects of dual endothelin- converting enzyme/neutral endopeptidase inhibitors, CGS 26303 and CGS 26393, on lipopolysaccharide or interleukin-1 beta-stimulated release of endothelin from guinea pig tracheal epithelial cells. J Cardiovasc Pharmacol. 1998;31 Suppl 1:S10-2. doi: 10.1097/00005344-199800001-00005. PMID: 9595386.

6: Watts SW, Thakali K, Smark C, Rondelli C, Fink GD. Big ET-1 processing into vasoactive peptides in arteries and veins. Vascul Pharmacol. 2007 Nov- Dec;47(5-6):302-12. doi: 10.1016/j.vph.2007.08.006. Epub 2007 Sep 7. PMID: 17904426; PMCID: PMC2719821.

7: Kwan AL, Lin CL, Chang CZ, Winardi D, Yen CP, Howng SL, Jeng AY. Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S160-2. doi: 10.1097/00005344-200036051-00050. PMID: 11078366.

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9: Goto K. [Prospects for endothelin-related drugs]. Nihon Rinsho. 2004 Sep;62 Suppl 9:673-81. Japanese. PMID: 15506472.

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