CGS 25462

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412772

CAS#: 147862-03-1

Description: CGS 25462 is a neutral endopeptidase (NEP) inhibitor.

Chemical Structure

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CGS 25462
CAS# 147862-03-1
Instruction

Theoretical Analysis

MedKoo Cat#: 412772
Name: CGS 25462
CAS#: 147862-03-1
Chemical Formula: C31H31N2O6P
Exact Mass: 558.19
Molecular Weight: 558.570
Elemental Analysis: C, 66.66; H, 5.59; N, 5.02; O, 17.19; P, 5.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CGS 25462; Cgs25462; Cgs-25462

IUPAC/Chemical Name: beta-Alanine, N-(3-(1,1'-biphenyl)-4-yl-N-((diphenoxyphosphinyl)methyl)-L-alanyl)-

InChi Key: JTQWXNZXTRVPHN-LJAQVGFWSA-N

InChi Code: InChI=1S/C31H31N2O6P/c34-30(35)20-21-32-31(36)29(22-24-16-18-26(19-17-24)25-10-4-1-5-11-25)33-23-40(37,38-27-12-6-2-7-13-27)39-28-14-8-3-9-15-28/h1-19,29,33H,20-23H2,(H,32,36)(H,34,35)/t29-/m0/s1

SMILES Code: O=C(O)CCNC([C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)NCP(OC3=CC=CC=C3)(OC4=CC=CC=C4)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 558.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maniara WM, Cipriano A, Powell ML. Quantitative analytical methods for the determination of a new hypertension drug, CGS 25462, and its metabolites (CGS 25659 and CGS 24592) in human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1998 Mar 20;706(2):287-94. doi: 10.1016/s0378-4347(97)00566-5. PMID: 9551815.

2: Pu Q, Amiri F, Gannon P, Schiffrin EL. Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats. J Hypertens. 2005 Feb;23(2):401-9. doi: 10.1097/00004872-200502000-00023. PMID: 15662229.

3: Pu Q, Touyz RM, Schiffrin EL. Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. J Hypertens. 2002 May;20(5):899-907. doi: 10.1097/00004872-200205000-00025. PMID: 12011651.

4: Trapani AJ, De Lombaert S, Erion MD, Ghai RD, Peppard JV, Lappe RW, Worcel M. The pharmacology of CGS 25462: a potent, orally bioavailable, long-acting inhibitor of neutral endopeptidase 24.11. J Hypertens Suppl. 1993 Dec;11(5):S220-1. PMID: 8158354.

5: De Lombaert S, Erion MD, Tan J, Blanchard L, el-Chehabi L, Ghai RD, Sakane Y, Berry C, Trapani AJ. N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors. J Med Chem. 1994 Feb 18;37(4):498-511. doi: 10.1021/jm00030a009. PMID: 8120868.

6: Perlini S. The potential advantage of omapatrilat: dual anti-fibrotic and anti-inflammatory effects in one single molecule. J Hypertens. 2005 Feb;23(2):273-5. doi: 10.1097/00004872-200502000-00007. PMID: 15662213.