CGS 12066A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412763

CAS#: 121741-03-5

Description: CGS 12066A is a drug which acts as a potent and selective agonist for the 5-HT1B receptor with lower affinity for the three 5-HT₂ receptor subtypes. It is used for studying the role of the 5-HT1B receptor in various processes including perception of pain and the sleep-wake cycle.

Chemical Structure

img
CGS 12066A
CAS# 121741-03-5
Instruction

Theoretical Analysis

MedKoo Cat#: 412763
Name: CGS 12066A
CAS#: 121741-03-5
Chemical Formula: C19H19F3N4O4
Exact Mass: 424.14
Molecular Weight: 424.380
Elemental Analysis: C, 53.77; H, 4.51; F, 13.43; N, 13.20; O, 15.08

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CGS 12066A; CGS12066A; CGS-12066A

IUPAC/Chemical Name: Pyrrolo(1,2-a)quinoxaline, 4-(4-methyl-1-piperazinyl)-7-(trifluoromethyl)-, ethanedioate (1:1)

InChi Key: RRTXUQKIVYYULV-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H17F3N4.C2H2O4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16;3-1(4)2(5)6/h2-6,11H,7-10H2,1H3;(H,3,4)(H,5,6)

SMILES Code: FC(C1=CC2=C(N3C(C(N4CCN(C)CC4)=N2)=CC=C3)C=C1)(F)F.O=C(O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 424.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Brumley MR, Robinson SR. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33. doi: 10.1037/0735-7044.119.3.821. PMID: 15998204.

2: Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011 Aug;15(4):269-81. doi: 10.1016/j.smrv.2010.11.003. Epub 2011 Apr 2. PMID: 21459634.

3: Bagdy E, Kiraly I, Harsing LG Jr. Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat. Neurochem Res. 2000 Nov;25(11):1465-73. doi: 10.1023/a:1007672008297. PMID: 11071365.

4: Sershen H, Hashim A, Lajtha A. Effect of ibogaine on cocaine-induced efflux of [3H] dopamine and [3H] serotonin from mouse striatum. Pharmacol Biochem Behav. 1996 Apr;53(4):863-9. doi: 10.1016/0091-3057(95)02098-5. PMID: 8801590.

5: Jeong HS, Jang MJ, Park JS. Effects of CGS-12066A on medial vestibular nuclear neurons. Brain Res. 2005 Mar 15;1038(1):118-21. doi: 10.1016/j.brainres.2005.01.025. PMID: 15748881.

6: Paul D, Yao D, Zhu P, Minor LD, Garcia MM. 5-hydroxytryptamine3 (5-HT3) receptors mediate spinal 5-HT antinociception: an antisense approach. J Pharmacol Exp Ther. 2001 Aug;298(2):674-8. PMID: 11454930.

7: Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores- Murrieta FJ, Villalón CM. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience. 2010 Jan 20;165(2):561-8. doi: 10.1016/j.neuroscience.2009.10.020. PMID: 19837141.

8: Joppa MA, Rowe RK, Meisel RL. Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters. Pharmacol Biochem Behav. 1997 Oct;58(2):349-53. doi: 10.1016/s0091-3057(97)00277-3. PMID: 9300591.

9: Middlemiss DN, Hutson PH. The 5-HT1B receptors. Ann N Y Acad Sci. 1990;600:132-47; discussion 347-48. doi: 10.1111/j.1749-6632.1990.tb16878.x. PMID: 2252306.

10: Lu CW, Lin TY, Huang SK, Wang SJ. 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Aug 30;86:122-130. doi: 10.1016/j.pnpbp.2018.05.019. Epub 2018 May 24. PMID: 29803926.