VISTA modulator 6809-0223

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463623

CAS#: 669749-25-1

Description: VISTA modulator 6809-0223 is a novel immune checkpoint VISTA (V-domain immunoglobulin suppressor of T-cell activation) modulator.

Chemical Structure

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VISTA modulator 6809-0223
CAS# 669749-25-1
Instruction

Theoretical Analysis

MedKoo Cat#: 463623
Name: VISTA modulator 6809-0223
CAS#: 669749-25-1
Chemical Formula: C18H17N7OS2
Exact Mass: 411.09
Molecular Weight: 411.502
Elemental Analysis: C, 52.54; H, 4.16; N, 23.83; O, 3.89; S, 15.58

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VISTA modulator 6809-0223; VISTA modulator 68090223; VISTA modulator 6809 0223;

IUPAC/Chemical Name: 2-((4,6-dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one

InChi Key: YIJOQQHVEVIMNS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17N7OS2/c1-9-4-5-14-13(6-9)10(2)19-16(21-14)23-17-20-12(7-15(26)22-17)8-27-18-25-24-11(3)28-18/h4-7H,8H2,1-3H3,(H2,19,20,21,22,23,26)

SMILES Code: O=C1NC(NC2=NC(C)=C3C=C(C)C=CC3=N2)=NC(CSC4=NN=C(C)S4)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 411.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zong L, Yu S, Mo S, Zhou Y, Xiang Y, Lu Z, Chen J. High VISTA Expression Correlates With a Favorable Prognosis in Patients With Colorectal Cancer. J Immunother. 2021 Jan;44(1):22-28. doi: 10.1097/CJI.0000000000000343. PMID: 33086339.