PGF2α | CAS# 4510-16-1 | induce labor and as an abortifacient

PGF2α
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412682

CAS#: 4510-16-1

Description: PGF2α pharmaceutically termed carboprost is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the luteal phase.

Chemical Structure

PGF2α

CAS# 4510-16-1

Instruction

Theoretical Analysis

MedKoo Cat#: 412682
Name: PGF2α
CAS#: 4510-16-1
Chemical Formula: C20H34O5
Exact Mass: 354.24
Molecular Weight: 354.490
Elemental Analysis: C, 67.77; H, 9.67; O, 22.57

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 237	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: PGF2α; Prostaglandin F2α

IUPAC/Chemical Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoic acid

InChi Key: PXGPLTODNUVGFL-YNNPMVKQSA-N

InChi Code: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1

SMILES Code: O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 354.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sharif NA, Klimko PG. Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility. Br J Pharmacol. 2019 Apr;176(8):1059-1078. doi: 10.1111/bph.14335. Epub 2018 Jun 7. PMID: 29679483; PMCID: PMC6451070.

2: Agas D, Marchetti L, Hurley MM, Sabbieti MG. Prostaglandin F2α: a bone remodeling mediator. J Cell Physiol. 2013 Jan;228(1):25-9. doi: 10.1002/jcp.24117. PMID: 22585670.

3: Ginther OJ, Domingues RR, Kennedy VC, Dangudubiyyam SV. Endogenous and exogenous effects of PGF2α during luteolysis in mares. Theriogenology. 2019 Jul 1;132:45-52. doi: 10.1016/j.theriogenology.2019.04.004. Epub 2019 Apr 9. PMID: 30991168.

4: Yang J, Pan M, Reinach PS, Chen R, Yu L, Zhou F, Zhang S, Qu J, Zhou X. Prostaglandin F2α Receptor Modulation Affects Eye Development in Guinea Pigs. Basic Clin Pharmacol Toxicol. 2018 Sep;123(3):263-270. doi: 10.1111/bcpt.13017. Epub 2018 May 29. PMID: 29604230.

5: Haimerl P, Heuwieser W, Arlt S. Short communication: Meta-analysis on therapy of bovine endometritis with prostaglandin F2α-An update. J Dairy Sci. 2018 Nov;101(11):10557-10564. doi: 10.3168/jds.2018-14933. Epub 2018 Aug 30. PMID: 30172399.

6: Pate JL, Johnson-Larson CJ, Ottobre JS. Life or death decisions in the corpus luteum. Reprod Domest Anim. 2012 Aug;47 Suppl 4:297-303. doi: 10.1111/j.1439-0531.2012.02089.x. PMID: 22827384.

7: Ucar EH, Cetin H, Atli MO. Effect of multiple low-dose PGF2α injections on the mature corpus luteum in non-pregnant bitches. Theriogenology. 2018 Jun;113:34-43. doi: 10.1016/j.theriogenology.2018.01.018. Epub 2018 Feb 22. PMID: 29454296.

8: Oosthuizen N, Lansford AC, Canal LB, Fontes PLP, Sanford CD, Dahlen CR, DiLorenzo N, Funston RN, Lamb GC. Comparison of two alternate PGF2α products in two estrus synchronization protocols in beef heifers. J Anim Sci. 2018 Apr 14;96(4):1388-1395. doi: 10.1093/jas/sky059. PMID: 29648600; PMCID: PMC6140874.

9: Colomo N, López-Siguero JP, Leiva I, Fuentes N, Rubio-Martín E, Omiste A, Guerrero M, Tapia MJ, Martín-Tejedor B, Ruiz de Adana MS, Olveira G. Relationship between glucose control, glycemic variability, and oxidative stress in children with type 1 diabetes. Endocrinol Diabetes Nutr. 2019 Nov;66(9):540-549. English, Spanish. doi: 10.1016/j.endinu.2018.12.010. Epub 2019 Mar 8. PMID: 30853269.

10: Ginther OJ, Beg MA. Dynamics of circulating progesterone concentrations before and during luteolysis: a comparison between cattle and horses. Biol Reprod. 2012 Jun 7;86(6):170. doi: 10.1095/biolreprod.112.099820. PMID: 22460665.

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