KAB-18 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463523

CAS#: unknown

Description: KAB-18 is a negative allosteric modulator (NAM) at Hα2 β4 nChR nicotinic cholinergic receptors.

Chemical Structure

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KAB-18 HCl
CAS# unknown
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 463523
Name: KAB-18 HCl
CAS#: unknown
Chemical Formula: C28H32ClNO2
Exact Mass: 449.21
Molecular Weight: 450.019
Elemental Analysis: C, 74.73; H, 7.17; Cl, 7.88; N, 3.11; O, 7.11

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: KAB-18 HCl; KAB18 HCl; KAB 18 HCl;

IUPAC/Chemical Name: (1-(3-phenylpropyl)piperidin-3-yl)methyl [1,1'-biphenyl]-2-carboxylate hydrochloride

InChi Key: VBAFEOBDSOCKKO-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H31NO2.ClH/c30-28(27-18-8-7-17-26(27)25-15-5-2-6-16-25)31-22-24-14-10-20-29(21-24)19-9-13-23-11-3-1-4-12-23;/h1-8,11-12,15-18,24H,9-10,13-14,19-22H2;1H

SMILES Code: O=C(OCC1CN(CCCC2=CC=CC=C2)CCC1)C3=C(C=CC=C3)C4=CC=CC=C4.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: KAB-18 is a negative allosteric modulator (NAM) at Hα2 β4 nChR nicotinic cholinergic receptors.
In vitro activity: The T58K mutation resulted in an eight-fold decrease in the potency of KAB-18, a compound that exhibits preferential antagonism for human α4β2 over α3β4 nAChRs, while the F118L mutation resulted in a loss of inhibitory activity for KAB-18 at concentrations up to 100 µM. These results demonstrate the selectivity of KAB-18 for human α4β2 nAChRs and validate the methods used for identifying the nAChR modulator binding site. Reference: PLoS One. 2011;6(9):e24949. https://pubmed.ncbi.nlm.nih.gov/21949802/
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 450.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors. PLoS One. 2011;6(9):e24949. doi: 10.1371/journal.pone.0024949. Epub 2011 Sep 15. PMID: 21949802; PMCID: PMC3174232.
In vitro protocol: 1. Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors. PLoS One. 2011;6(9):e24949. doi: 10.1371/journal.pone.0024949. Epub 2011 Sep 15. PMID: 21949802; PMCID: PMC3174232.
In vivo protocol: TBD

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