AZB-002

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575191

CAS#: 255716-41-7

Description: AZB-002 is a tetrafluoroborate salt that forms adducts with DNA.

Chemical Structure

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AZB-002
CAS# 255716-41-7
Instruction

Theoretical Analysis

MedKoo Cat#: 575191
Name: AZB-002
CAS#: 255716-41-7
Chemical Formula: C25H19BF4N2
Exact Mass: 434.16
Molecular Weight: 434.240
Elemental Analysis: C, 69.15; H, 4.41; B, 2.49; F, 17.50; N, 6.45

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AZB-002; AZB002; AZB 002

IUPAC/Chemical Name: 1H-Benzimidazolium, 1-methyl-2-(2-phenylethynyl)-3-(3-phenyl-2-propyn-1-yl)-, tetrafluoroborate(1-) (1:1)

InChi Key: DZBIRJKUFWMYFO-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H19N2.BF4/c1-26-23-16-8-9-17-24(23)27(20-10-15-21-11-4-2-5-12-21)25(26)19-18-22-13-6-3-7-14-22;2-1(3,4)5/h2-9,11-14,16-17H,20H2,1H3;/q+1;-1

SMILES Code: Cn1c(C#Cc2ccccc2)[n+](CC#Cc3ccccc3)c4ccccc14.F[B-](F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 434.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Sherman CL, Pierce SE, Brodbelt JS, Tuesuwan B, Kerwin SM. Identification of the adduct between a 4-Aza-3-ene-1,6-diyne and DNA using electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2006 Oct;17(10):1342-1352. doi: 10.1016/j.jasms.2006.05.015. Epub 2006 Jul 26. PMID: 16872840.

2. Tuntiwechapikul W, David WM, Kumar D, Salazar M, Kerwin SM. DNA modification by 4-aza-3-ene-1,6-diynes: DNA cleavage, pH-dependent cytosine-specific interactions, and cancer cell cytotoxicity. Biochemistry. 2002 Apr 23;41(16):5283-90. doi: 10.1021/bi025535e. PMID: 11955078.