Quindoxin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 412548

CAS#: 2423-66-7

Description: Quindoxin is a biochemical

Chemical Structure

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Quindoxin
CAS# 2423-66-7
Instruction

Theoretical Analysis

MedKoo Cat#: 412548
Name: Quindoxin
CAS#: 2423-66-7
Chemical Formula: C8H6N2O2
Exact Mass: 162.04
Molecular Weight: 162.150
Elemental Analysis: C, 59.26; H, 3.73; N, 17.28; O, 19.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quindoxin; NSC21653; NSC-21653 NSC 21653

IUPAC/Chemical Name: quinoxaline 1,4-dioxide

InChi Key: CKIHZSGJPSDCNC-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H6N2O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H

SMILES Code: O=n(ccn1=O)c2c1cccc2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 162.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Suter W, Rosselet A, Knüsel F. Mode of action of quindoxin and substituted quinoxaline-di-N-oxides on Escherichia coli. Antimicrob Agents Chemother. 1978 May;13(5):770-83. doi: 10.1128/aac.13.5.770. PMID: 352264; PMCID: PMC352330.

2: Beutin L, Preller E, Kowalski B. Mutagenicity of quindoxin, its metabolites, and two substituted quinoxaline-di-N-oxides. Antimicrob Agents Chemother. 1981 Sep;20(3):336-43. doi: 10.1128/aac.20.3.336. PMID: 7030199; PMCID: PMC181697.

3: Zaynoun S, Johnson BE, Frain-Bell W. The investigation of quindoxin photosensitivity. Contact Dermatitis. 1976 Dec;2(6):343-52. doi: 10.1111/j.1600-0536.1976.tb03073.x. PMID: 1032128.

4: Hennessey TD, Edwards JR. Antibacterial properties of quindoxin: a new growth-promoting agent. Vet Rec. 1972 Feb 12;90(7):187-91. doi: 10.1136/vr.90.7.187. PMID: 4553051.

5: Frain-Bell W, Gardiner J. Photocontact dermatitis due to quindoxin. Contact Dermatitis. 1975 Aug;1(4):256-7. doi: 10.1111/j.1600-0536.1975.tb05411.x. PMID: 139237.

6: Voogd CE, van der Stel JJ, Jacobs JJ. The mutagenic action of quindoxin, carbadox, olaquindox and some other N-oxides on bacteria and yeast. Mutat Res. 1980 Jul;78(3):233-42. doi: 10.1016/0165-1218(80)90104-4. PMID: 7001216.

7: Scheutwinkel-Reich M, vd Hude W. Sister-chromatid exchange in Chinese hamster V79 cells exposed to quindoxin, carbadox and olaquindox. Mutat Res. 1984 Apr;139(4):199-202. doi: 10.1016/0165-7992(84)90128-3. PMID: 6717485.

8: de Vries H, Bojarski J, Donker AA, Bakri A, Beyersbergen van Henegouwen GM. Photochemical reactions of quindoxin, olaquindox, carbadox and cyadox with protein, indicating photoallergic properties. Toxicology. 1990 Jul;63(1):85-95. doi: 10.1016/0300-483x(90)90071-n. PMID: 2382272.

9: Scott KW, Dawson TA. Photo-contact dermatitis arising from the presence of quindoxin in animal feeding stuffs. Br J Dermatol. 1974 May;90(5):543-6. doi: 10.1111/j.1365-2133.1974.tb06450.x. PMID: 4833790.

10: Inbaraj JJ, Motten AG, Chignell CF. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues. Chem Res Toxicol. 2003 Feb;16(2):164-70. doi: 10.1021/tx0256073. PMID: 12588187.