SSR-69071
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574880

CAS#: 344930-95-6

Description: SSR-69071 is a potent inhibitor of neutrophil elastase.

Chemical Structure

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SSR-69071
CAS# 344930-95-6
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 574880
Name: SSR-69071
CAS#: 344930-95-6
Chemical Formula: C27H32N4O7S
Exact Mass: 556.20
Molecular Weight: 556.630
Elemental Analysis: C, 58.26; H, 5.79; N, 10.07; O, 20.12; S, 5.76

Price and Availability

Size Price Availability Quantity
1mg USD 240 2 Weeks
5mg USD 475 2 Weeks
10mg USD 680 2 Weeks
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Synonym: SSR-69071; SSR 69071; SSR69071

IUPAC/Chemical Name: 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one

InChi Key: DRZXDZYWZSKFDL-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H32N4O7S/c1-18(2)20-14-19(36-3)15-22-25(20)27(33)31(39(22,34)35)17-38-23-16-24(32)30-11-7-8-21(26(30)28-23)37-13-12-29-9-5-4-6-10-29/h7-8,11,14-16,18H,4-6,9-10,12-13,17H2,1-3H3

SMILES Code: O=C1N(C2=NC(OCN3S(C(C=C(OC)C=C4C(C)C)=C4C3=O)(=O)=O)=C1)C=CC=C2OCCN5CCCCC5

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: SSR-69071 is a potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme). It is selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively).
In vitro activity: To be determined
In vivo activity: This study demonstrates that SSR-69071 is a selective, orally active, and potent inhibitor of human leukocyte elastase (HLE) with good penetration in respiratory tissues. Bronchoalveolar lavage fluid from mice orally treated with SSR69071 inhibits HLE. SSR-69071 significantly decreased the acute lung hemorrhage induced by HLE (ED(50) = 2.8 mg/kg p.o.) in mice. SSR-69071 also prevented carrageenan- (ED(30) = 2.2 mg/kg) and HLE-induced (ED(30) = 2.7 mg/kg) paw edema in rats after p.o. administration. Reference: J Pharmacol Exp Ther. 2003 May;305(2):451-9. https://pubmed.ncbi.nlm.nih.gov/12606659/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.0 44.91
Ethanol 10.0 17.97

Preparing Stock Solutions

The following data is based on the product molecular weight 556.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Kapui Z, Varga M, Urban-Szabo K, Mikus E, Szabo T, Szeredi J, Batori S, Finance O, Aranyi P. Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. J Pharmacol Exp Ther. 2003 May;305(2):451-9. doi: 10.1124/jpet.102.044263. Epub 2003 Feb 11. PMID: 12606659. 2. Bidouard JP, Duval N, Kapui Z, Herbert JM, O'Connor SE, Janiak P. SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur J Pharmacol. 2003 Feb 7;461(1):49-52. doi: 10.1016/s0014-2999(03)01298-6. PMID: 12568915.
In vitro protocol: To be determined
In vivo protocol: 1. Kapui Z, Varga M, Urban-Szabo K, Mikus E, Szabo T, Szeredi J, Batori S, Finance O, Aranyi P. Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. J Pharmacol Exp Ther. 2003 May;305(2):451-9. doi: 10.1124/jpet.102.044263. Epub 2003 Feb 11. PMID: 12606659. 2. Bidouard JP, Duval N, Kapui Z, Herbert JM, O'Connor SE, Janiak P. SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur J Pharmacol. 2003 Feb 7;461(1):49-52. doi: 10.1016/s0014-2999(03)01298-6. PMID: 12568915.

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1. Kapui, Z., Varga, M., Urban-Szabo, K., et al. Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. J. Pharmacol. Exp. Ther. 305(2), 451-459 (2003).

2. Bidouard, J.-P., Duval, N., Kapui, Z., et al. SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia - reperfusion injury. Eur. J. Pharm. 461(1), 49-52 (2003).