SGC-CK2-1
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463062

CAS#: 2470424-39-4

Description: SGC-CK2-1 is a novel potent CK2 inhibitor, showing equal potency in binding to both catalytic subunits of CK2: CK2α (CSNK2A1) and CK2α' (CSNK2A2). This compound shows equal potency in binding to both catalytic subunits of CK2: CK2α (CSNK2A1) and CK2α' (CSNK2A2). Casein kinase 2 (CK2) is highly expressed in cancer and has been considered a potential therapeutic target.

Chemical Structure

img
SGC-CK2-1
CAS# 2470424-39-4
Instruction

Theoretical Analysis

MedKoo Cat#: 463062
Name: SGC-CK2-1
CAS#: 2470424-39-4
Chemical Formula: C20H21N7O
Exact Mass: 375.18
Molecular Weight: 375.440
Elemental Analysis: C, 63.98; H, 5.64; N, 26.12; O, 4.26

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
25mg USD 700 2 Weeks
50mg USD 1150 2 Weeks
Bulk inquiry

Synonym: SGC-CK2-1; SGCCK2-1; SGC CK2-1; SGC-CK21; SGC-CK2-1; SGC-CK2 1;

IUPAC/Chemical Name: N-[5-[[3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methylphenyl]propanamide

InChi Key: YKDZIFFKQUNVHH-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N7O/c1-3-19(28)25-16-8-15(5-4-12(16)2)23-17-9-18(24-14-6-7-14)27-20(26-17)13(10-21)11-22-27/h4-5,8-9,11,14,24H,3,6-7H2,1-2H3,(H,23,26)(H,25,28)

SMILES Code: CCC(NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 375.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Licciardello MP, Workman P. A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2. Trends Pharmacol Sci. 2021 May;42(5):313-315. doi: 10.1016/j.tips.2021.02.002. Epub 2021 Mar 23. PMID: 33771354.


2: Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10. doi: 10.1016/j.chembiol.2020.12.013. Epub 2021 Jan 22. PMID: 33484635.