SJF 1521
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462819

CAS#: 2230821-40-4

Description: SJF 1521 is a selective EGFR Degrader. It induces degradation of EGFR in OVCAR8 cells.

Chemical Structure

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SJF 1521
CAS# 2230821-40-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462819
Name: SJF 1521
CAS#: 2230821-40-4
Chemical Formula: C57H61ClFN7O9S
Exact Mass: 1,073.39
Molecular Weight: 1,074.660
Elemental Analysis: C, 63.71; H, 5.72; Cl, 3.30; F, 1.77; N, 9.12; O, 13.40; S, 2.98

Price and Availability

Size Price Availability Quantity
5mg USD 720 2 Weeks
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Synonym: SJF 1521;

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(tert-butyl)-14-(4-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)phenoxy)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key: XZNORRXEBCTXPB-KHBXAZQSSA-N

InChi Code: InChI=1S/C57H61ClFN7O9S/c1-36-52(76-35-63-36)40-10-8-37(9-11-40)30-60-55(69)49-29-44(67)31-66(49)56(70)53(57(2,3)4)65-51(68)33-73-23-22-71-20-21-72-24-25-74-45-16-12-39(13-17-45)41-14-18-48-46(27-41)54(62-34-61-48)64-43-15-19-50(47(58)28-43)75-32-38-6-5-7-42(59)26-38/h5-19,26-28,34-35,44,49,53,67H,20-25,29-33H2,1-4H3,(H,60,69)(H,65,68)(H,61,62,64)/t44-,49+,53-/m1/s1

SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(COCCOCCOCCOC4=CC=C(C=C4)C5=CC6=C(C=C5)N=CN=C6NC7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7)=O)C(C)(C)C)=O)=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: SJF 1521 induces degradation of EGFR in OVCAR8 cells. It exhibits selectivity for EGFR, including mutant forms, over HER2.
In vitro activity: To be determined
In vivo activity: To be determined

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 107.5 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1,074.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: To be determined
In vitro protocol: To be determined
In vivo protocol: To be determined

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