Siduron

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462655

CAS#: 1982-49-6

Description: Siduron is compound that is used in herbicides

Chemical Structure

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Siduron
CAS# 1982-49-6
Instruction

Theoretical Analysis

MedKoo Cat#: 462655
Name: Siduron
CAS#: 1982-49-6
Chemical Formula: C14H20N2O
Exact Mass: 232.16
Molecular Weight: 232.327
Elemental Analysis: C, 72.38; H, 8.68; N, 12.06; O, 6.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NSC131951; NSC 131951; NSC-131951;

IUPAC/Chemical Name: 1-(2-methylcyclohexyl)-3-phenylurea

InChi Key: JXVIIQLNUPXOII-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H20N2O/c1-11-7-5-6-10-13(11)16-14(17)15-12-8-3-2-4-9-12/h2-4,8-9,11,13H,5-7,10H2,1H3,(H2,15,16,17)

SMILES Code: CC1CCCCC1NC(Nc2ccccc2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 232.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jiang R, Wang M, Chen W, Li X. Ecological risk evaluation of combined pollution of herbicide siduron and heavy metals in soils. Sci Total Environ. 2018 Jun 1;626:1047-1056. doi: 10.1016/j.scitotenv.2018.01.135. Epub 2018 Feb 19. PMID: 29898513.

2: Jiang R, Wang M, Chen W. Characterization of adsorption and desorption of lawn herbicide siduron in heavy metal contaminated soils. Chemosphere. 2018 Aug;204:483-491. doi: 10.1016/j.chemosphere.2018.04.045. Epub 2018 Apr 9. PMID: 29679869.

3: Uwizeyimana H, Wang M, Chen W, Khan K. Ecotoxicological effects of binary mixtures of siduron and Cd on mRNA expression in the earthworm Eisenia fetida. Sci Total Environ. 2018 Jan 1;610-611:657-665. doi: 10.1016/j.scitotenv.2017.07.265. Epub 2017 Aug 17. PMID: 28822934.

4: Uwizeyimana H, Wang M, Chen W. Evaluation of combined noxious effects of siduron and cadmium on the earthworm Eisenia fetida. Environ Sci Pollut Res Int. 2017 Feb;24(6):5349-5359. doi: 10.1007/s11356-016-8220-x. Epub 2016 Dec 24. PMID: 28013463.

5: Li X, Wang M, Chen W, Jiang R. Evaluation of combined toxicity of Siduron and cadmium on earthworm (Eisenia fetida) using Biomarker Response Index. Sci Total Environ. 2019 Jan 1;646:893-901. doi: 10.1016/j.scitotenv.2018.07.380. Epub 2018 Jul 27. PMID: 30235648.

6: Jiang R, Wang M, Chen W, Li X, Balseiro-Romero M, Baveye PC. Ecological risk of combined pollution on soil ecosystem functions: Insight from the functional sensitivity and stability. Environ Pollut. 2019 Dec;255(Pt 1):113184. doi: 10.1016/j.envpol.2019.113184. Epub 2019 Sep 10. PMID: 31541819.

7: Zhang L, Hang P, Hu Q, Chen XL, Zhou XY, Chen K, Jiang JD. Degradation of Phenylurea Herbicides by a Novel Bacterial Consortium Containing Synergistically Catabolic Species and Functionally Complementary Hydrolases. J Agric Food Chem. 2018 Nov 28;66(47):12479-12489. doi: 10.1021/acs.jafc.8b03703. Epub 2018 Nov 13. PMID: 30407808.

8: Newman JW, Denton DL, Morisseau C, Koger CS, Wheelock CE, Hinton DE, Hammock BD. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ Health Perspect. 2001 Jan;109(1):61-6. doi: 10.1289/ehp.0110961. PMID: 11171526; PMCID: PMC1242052.

9: Belasco IJ, Langsdorf WP. Synthesis of carbon-14 labeled siduron and its fate in soil. J Agric Food Chem. 1969 Sep;17(5):1004-7. doi: 10.1021/jf60165a034. PMID: 21428336.

10: Kong L, Kadokami K, Wang S, Duong HT, Chau HTC. Monitoring of 1300 organic micro-pollutants in surface waters from Tianjin, North China. Chemosphere. 2015 Mar;122:125-130. doi: 10.1016/j.chemosphere.2014.11.025. Epub 2014 Dec 3. PMID: 25479805.

11: Saraji M, Tansazan N. Application of dispersive liquid-liquid microextraction for the determination of phenylurea herbicides in water samples by HPLC-diode array detection. J Sep Sci. 2009 Dec;32(23-24):4186-92. doi: 10.1002/jssc.200900438. PMID: 19877151.

12: Ealy DB, Gorman RR, Kaiser FR, Scroggs RE. Determination of siduron in fertilizers by flame ionization gas-liquid chromatography. J Assoc Off Anal Chem. 1974 Jan;57(1):60-1. PMID: 4814328.

13: Jordan LS, Zurqiyah AA, De Mur AR, Clerx WA. Metabolism of siduron in kentucky bluegrass (Poa pratensis L.). J Agric Food Chem. 1975 Mar- Apr;23(2):286-90. doi: 10.1021/jf60198a058. PMID: 1133302.

14: Belasco IJ, Reiser RW. Metabolic fate of siduron in the animal. J Agric Food Chem. 1969 Sep;17(5):1000-3. doi: 10.1021/jf60165a033. PMID: 21428335.

15: Li Y, George JE, McCarty CL, Wendelken SC. Compliance analysis of phenylurea and related compounds in drinking water by liquid chromatography/electrospray ionization/mass spectrometry coupled with solid-phase extraction. J Chromatogr A. 2006 Nov 17;1134(1-2):170-6. doi: 10.1016/j.chroma.2006.08.081. Epub 2006 Sep 25. PMID: 16997312.

16: Mou RX, Chen MX, Zhi JL. Simultaneous determination of 15 phenylurea herbicides in rice and corn using HPLC with fluorescence detection combined with UV decomposition and post-column derivatization. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 15;875(2):437-43. doi: 10.1016/j.jchromb.2008.09.022. Epub 2008 Sep 25. PMID: 18838312.

17: Hou X, Huang X, Ai Z, Zhao J, Zhang L. Ascorbic acid/Fe@Fe2O3: A highly efficient combined Fenton reagent to remove organic contaminants. J Hazard Mater. 2016 Jun 5;310:170-8. doi: 10.1016/j.jhazmat.2016.01.020. Epub 2016 Feb 18. PMID: 26921510.

18: Zilkah S, Osband ME, McCaffrey R. Effect of inhibitors of plant cell division on mammalian tumor cells in vitro. Cancer Res. 1981 May;41(5):1879-83. PMID: 7214355.

19: Li X, Wang M, Jiang R, Zheng L, Chen W. Evaluation of joint toxicity of heavy metals and herbicide mixtures in soils to earthworms (Eisenia fetida). J Environ Sci (China). 2020 Aug;94:137-146. doi: 10.1016/j.jes.2020.03.055. Epub 2020 May 5. PMID: 32563477.

20: Weinberger M, Bollag JM. Degradation of chlorbromuron and related compounds by the fungus Rhizoctonia solani. Appl Microbiol. 1972 Nov;24(5):750-4. PMID: 4640737; PMCID: PMC380657.