Zatolmilast
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462518

CAS#: 1606974-33-7

Description: Zatolmilast is a phosphodiesterase IV inhibitor.

Chemical Structure

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Zatolmilast
CAS# 1606974-33-7
Instruction

Theoretical Analysis

MedKoo Cat#: 462518
Name: Zatolmilast
CAS#: 1606974-33-7
Chemical Formula: C21H15ClF3NO2
Exact Mass: 405.07
Molecular Weight: 405.801
Elemental Analysis: C, 62.16; H, 3.73; Cl, 8.74; F, 14.05; N, 3.45; O, 7.89

Price and Availability

Size Price Availability Quantity
5mg USD 460 2 Weeks
10mg USD 810 2 Weeks
25mg USD 1440 2 Weeks
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Synonym: Zatolmilast; BPN14770; BPN-14770; BPN 14770

IUPAC/Chemical Name: (4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid

InChi Key: LTSUMTMGJHPGFX-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H15ClF3NO2/c22-17-3-1-2-16(12-17)18-9-15(10-19(26-18)21(23,24)25)8-13-4-6-14(7-5-13)11-20(27)28/h1-7,9-10,12H,8,11H2,(H,27,28)

SMILES Code: O=C(O)CC1=CC=C(CC2=CC(C3=CC=CC(Cl)=C3)=NC(C(F)(F)F)=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: WHO Drug Information, Vol. 34, No. 2, 2020

2: Ricciarelli R, Brullo C, Prickaerts J, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease. Sci Rep. 2017;7:46320. Published 2017 Apr 12. doi:10.1038/srep46320

3: Gurney ME, Nugent RA, Mo X, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019;62(10):4884-4901. doi:10.1021/acs.jmedchem.9b00193