WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 535111
CAS#: N/A
Description: Xantholipin B is a Novel antibiotic, showing 3- to 10-fold greater cytotoxicity than Xantholipin against a select panel of human cancer cell lines, demonstrating powerful antimicrobial activity against both Gram-positive bacteria and fungi.
MedKoo Cat#: 535111
Name: Xantholipin B
CAS#: N/A
Chemical Formula: C27H18ClNO9
Exact Mass: 535.067
Molecular Weight: 535.889
Elemental Analysis: C, 60.52; H, 3.39; Cl, 6.62; N, 2.61; O, 26.87
This product is not in stock, which may be available by custom synthesis.
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Synonym: Xantholipin B
IUPAC/Chemical Name: 3-Chloro-10,15,16-trihydroxy-4-methoxy-12-methyl-8a,13-dihydro-9H-chromeno[2',3':6,7][1,3]dioxino[4',5',6':4,5]naphtho[2,1-g]isoquinoline-14,17-dione
InChi Key: FRHNWMLBXWSDRM-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H18ClNO9/c1-8-5-10-15(27(34)29-8)21(32)14-11(19(10)30)6-13-16-17(14)22(33)18-20(31)9-3-4-12(28)24(35-2)23(9)38-26(18)25(16)37-7-36-13/h3-5,13,30,32-33H,6-7H2,1-2H3,(H,29,34)
SMILES Code: O=C1NC(C)=CC2=C1C(O)=C3C(CC4C5=C3C(O)=C(C(C6=C(O7)C(OC)=C(Cl)C=C6)=O)C7=C5OCO4)=C2O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 535.889 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wu S, Huang T, Xie D, Wo J, Wang X, Deng Z, Lin S. Xantholipin B produced by the stnR inactivation mutant Streptomyces flocculus CGMCC 4.1223 WJN-1. J Antibiot (Tokyo). 2017 Jan;70(1):90-95. doi: 10.1038/ja.2016.60. Epub 2016 Jun 22. PMID: 27328868.
