AZ10606120 dihydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574335

CAS#: 607378-18-7

Description: AZ10606120 dihydrochloride is a potent, specific P2X7 receptor antagonist that strongly inhibits tumor growth in B16-inoculated C57Bl/6 mice.

Chemical Structure

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AZ10606120 dihydrochloride
CAS# 607378-18-7
Instruction

Theoretical Analysis

MedKoo Cat#: 574335
Name: AZ10606120 dihydrochloride
CAS#: 607378-18-7
Chemical Formula: C25H36Cl2N4O2
Exact Mass: 494.22
Molecular Weight: 495.490
Elemental Analysis: C, 60.60; H, 7.32; Cl, 14.31; N, 11.31; O, 6.46

Price and Availability

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10mg USD 450 2 Weeks
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Synonym: AZ10606120 dihydrochloride, AZ10606120 2HCl

IUPAC/Chemical Name: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride

InChi Key: BVFONFUUWORSPO-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H34N4O2.2ClH/c30-9-8-26-6-7-27-23-5-4-20-21(28-23)2-1-3-22(20)29-24(31)16-25-13-17-10-18(14-25)12-19(11-17)15-25;;/h1-5,17-19,26,30H,6-16H2,(H,27,28)(H,29,31);2*1H

SMILES Code: O=C(NC1=C2C=CC(NCCNCCO)=NC2=CC=C1)CC3(C4)CC5CC4CC(C5)C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 495.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Yan Z, et al. J Neurosci. 2010 Oct 20;30(42):14213-24.

2. Mohammed A, et al. Oncotarget. 2017 Oct 26;8(58):97822-97834.

3. Adinolfi E, et al. Cancer Res. 2012 Jun 15;72(12):2957-69.

4. Michel AD, et al. Br J Pharmacol. 2008 Feb;153(4):737-50.