JBJ-03-142-02
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462088

CAS#: 2068806-31-3

Description: JBJ-03-142-02 is a highly potent EGFR and ErbB2 inhibitor that inhibits wild type and mutated receptors.

Chemical Structure

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JBJ-03-142-02
CAS# 2068806-31-3
Instruction

Theoretical Analysis

MedKoo Cat#: 462088
Name: JBJ-03-142-02
CAS#: 2068806-31-3
Chemical Formula: C25H22FN7O3
Exact Mass: 487.18
Molecular Weight: 487.495
Elemental Analysis: C, 61.60; H, 4.55; F, 3.90; N, 20.11; O, 9.85

Price and Availability

Size Price Availability Quantity
10mg USD 550 2 Weeks
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Synonym: JBJ-03-142-02

IUPAC/Chemical Name: (4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate

InChi Key: IFRXGTCPIGRGHP-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H22FN7O3/c1-3-23(34)29-19-5-4-6-21(13-19)33(25(35)36-16-17-7-9-18(26)10-8-17)22-11-12-27-24(31-22)30-20-14-28-32(2)15-20/h3-15H,1,16H2,2H3,(H,29,34)(H,27,30,31)

SMILES Code: O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 487.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor Dr. Jaebong Jang, Dr. Jieun Son, Dr. Eunyoung Park, Dr. Takayuki Kosaka, Dr. Jamie A. Saxon, Dr. Dries J. H. De Clercq, Dr. Hwan Geun Choi, Dr. Junko Tanizaki, Dr. Michael J. Eck, Dr. Pasi A. Jänne, Dr. Nathanael S. Gray Angew Chem Int Ed Engl. Author manuscript; available in PMC 2018 Sep 3.Published in final edited form as: Angew Chem Int Ed Engl. 2018 Sep 3; 57(36): 11629 11633. Published online 2018 Aug 3. doi: 10.1002/anie.201805187 PMCID: PMC6118895