Nevirapine-d3
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534609

CAS#: 1051419-24-9

Description: Nevirapine-d3 is deuterized nevirapine, reducing P450 metabolite formation, impacting on phase II metabolism and hepatocyte protein expression.


Price and Availability

Size Price Shipping out time Quantity
3mg USD 480 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

Nevirapine-d3 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 534609
Name: Nevirapine-d3
CAS#: 1051419-24-9
Chemical Formula: C15H11D3N4O
Exact Mass: 269.1356
Molecular Weight: 269.3223
Elemental Analysis: C, 66.90; H, 6.36; N, 20.80; O, 5.94


Synonym: Nevirapine-d3; Nevirapine d3; Nevirapined3; 12-D3NVP; 12 D3NVP; 12D3NVP

IUPAC/Chemical Name: 2-cyclopropyl-7-(trideuteriomethyl)-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one

InChi Key: NQDJXKOVJZTUJA-FIBGUPNXSA-N

InChi Code: InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)/i1D3

SMILES Code: O=C1NC2=C(C([2H])([2H])[2H])C=CN=C2N(C3CC3)C4=C1C=CC=N4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Notter J, Bregenzer A, Vernazza P, Kahlert CR. Nevirapine in HIV maintenance therapy - can "old drugs" survive in current HIV management? Swiss Med Wkly. 2019 Apr 24;149:w20053. doi: 10.4414/smw.2019.20053. PMID: 31017649.

2: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Nevirapine. 2014 Feb 2. PMID: 31644202.

3: Neary M, Chappell CA, Scarsi KK, Nakalema S, Matovu J, Achilles SL, Chen BA, Siccardi M, Owen A, Lamorde M. Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART. J Antimicrob Chemother. 2019 Oct 1;74(10):3003-3010. doi: 10.1093/jac/dkz298. PMID: 31299074; PMCID: PMC6753484.

4: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Nevirapine. 2020 Jan 20. PMID: 30000595.

5: Rehman N, Nguyen H. Nevirapine. 2020 Feb 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 32119364.

6: Popovic M, Shenton JM, Chen J, Baban A, Tharmanathan T, Mannargudi B, Abdulla D, Uetrecht JP. Nevirapine hypersensitivity. Handb Exp Pharmacol. 2010;(196):437-51. doi: 10.1007/978-3-642-00663-0_15. PMID: 20020271.

7: Milinkovic A, Martínez E. Nevirapine in the treatment of HIV. Expert Rev Anti Infect Ther. 2004 Jun;2(3):367-73. doi: 10.1586/14787210.2.3.367. PMID: 15482202.

8: Taiwo BO. Nevirapine toxicity. Int J STD AIDS. 2006 Jun;17(6):364-9; quiz 370. doi: 10.1258/095646206777323346. PMID: 16734954.

9: Huang L, Carey V, Lindsey JC, Marzan F, Gingrich D, Graham B, Barlow-Mosha L, Ssemambo PK, Kamthunzi P, Nachman S, Parikh S, Aweeka FT; IMPAACT P1079 protocol team. Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children. PLoS One. 2017 Oct 24;12(10):e0186589. doi: 10.1371/journal.pone.0186589. PMID: 29065172; PMCID: PMC5655345.

10: Awodele O, Popoola T, Rotimi K, Ikumawoyi V, Okunowo W. Antioxidant modulation of nevirapine induced hepatotoxicity in rats. Interdiscip Toxicol. 2015 Mar;8(1):8-14. doi: 10.1515/intox-2015-0002. PMID: 27486354; PMCID: PMC4961920.