FR 33289

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 534585

CAS#: 73240-14-9

Description: FR 33289 is an antibiotic chemical.

Chemical Structure

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FR 33289
CAS# 73240-14-9
Instruction

Theoretical Analysis

MedKoo Cat#: 534585
Name: FR 33289
CAS#: 73240-14-9
Chemical Formula: C5H11NNaO6P
Exact Mass: 235.02
Molecular Weight: 235.108
Elemental Analysis: C, 25.54; H, 4.72; N, 5.96; Na, 9.78; O, 40.83; P, 13.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: FR 33289; FR33289; FR-33289

IUPAC/Chemical Name: Phosphonic acid, (3-(acetylhydroxyamino)-2-hydroxypropyl)-, monosodium salt, (R)-

InChi Key: GIVARPDUQVHFMQ-NUBCRITNSA-M

InChi Code: InChI=1S/C5H12NO6P.Na/c1-4(7)6(9)2-5(8)3-13(10,11)12;/h5,8-9H,2-3H2,1H3,(H2,10,11,12);/q;+1/p-1/t5-;/m1./s1

SMILES Code: O[C@H](CN(C(C)=O)O)CP([O-])(O)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 235.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Okuhara M, Kuroda Y, Goto T, Okamoto M, Terano H, Kohsaka M, Aoki H, Imanaka H. Studies on new phosphonic acid antibiotics. III. Isolation and characterization of FR-31564, FR-32863 and FR-33289. J Antibiot (Tokyo). 1980 Jan;33(1):24-8. doi: 10.7164/antibiotics.33.24. PMID: 6768705.


2: Kuroda Y, Okuhara M, Goto T, Okamoto M, Terano H, Kohsaka M, Aoki H, Imanaka H. Studies on new phosphonic acid antibiotics. IV. Structure determination of FR-33289, FR-31564 and FR-32863. J Antibiot (Tokyo). 1980 Jan;33(1):29-35. doi: 10.7164/antibiotics.33.29. PMID: 7372547.


3: Johannes TW, DeSieno MA, Griffin BM, Thomas PM, Kelleher NL, Metcalf WW, Zhao H. Deciphering the late biosynthetic steps of antimalarial compound FR-900098. Chem Biol. 2010 Jan 29;17(1):57-64. doi: 10.1016/j.chembiol.2009.12.009. PMID: 20142041; PMCID: PMC2819980.


4: Li C, Junaid M, Almuqri EA, Hao S, Zhang H. Structural analysis of a phosphonate hydroxylase with an access tunnel at the back of the active site. Acta Crystallogr F Struct Biol Commun. 2016 May;72(Pt 5):362-8. doi: 10.1107/S2053230X16004933. Epub 2016 Apr 22. PMID: 27139827; PMCID: PMC4854563.


5: DeSieno MA, van der Donk WA, Zhao H. Characterization and application of the Fe(II) and α-ketoglutarate dependent hydroxylase FrbJ. Chem Commun (Camb). 2011 Sep 28;47(36):10025-7. doi: 10.1039/c1cc13597j. Epub 2011 Aug 10. PMID: 21829824; PMCID: PMC4091617.


6: Iguchi E, Okuhara M, Kohsaka M, Aoki H, Imanaka H. Studies on new phosphonic acid antibiotics. II. Taxonomic studies on producing organisms of the phosphonic acid and related compounds. J Antibiot (Tokyo). 1980 Jan;33(1):19-23. PMID: 7372546.